Reduced oxidative capacity in macrophages results in systemic insulin resistance

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dc.contributor.authorJung, Saet-Byelko
dc.contributor.authorChoi, Min Jeongko
dc.contributor.authorRyu, Dongryeolko
dc.contributor.authorYi, Hyon-Seungko
dc.contributor.authorLee, Seong Eunko
dc.contributor.authorChang, Joon Youngko
dc.contributor.authorChung, Hyo Kyunko
dc.contributor.authorKim, Yong Kyungko
dc.contributor.authorKang, Seul Giko
dc.contributor.authorLee, Ju Heeko
dc.contributor.authorKim, Koon Soonko
dc.contributor.authorKim, Hyun Jinko
dc.contributor.authorKim, Cuk-Seongko
dc.contributor.authorLee, Chul-Hoko
dc.contributor.authorWilliams, Robert W.ko
dc.contributor.authorKim, Hailko
dc.contributor.authorLee, Heung Kyuko
dc.contributor.authorAuwerx, Johanko
dc.contributor.authorShong, Minhoko
dc.date.accessioned2018-06-16T07:38:04Z-
dc.date.available2018-06-16T07:38:04Z-
dc.date.created2018-06-12-
dc.date.created2018-06-12-
dc.date.created2018-06-12-
dc.date.created2018-06-12-
dc.date.created2018-06-12-
dc.date.issued2018-04-
dc.identifier.citationNATURE COMMUNICATIONS, v.9-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10203/242554-
dc.description.abstractOxidative functions of adipose tissue macrophages control the polarization of M1-like and M2-like phenotypes, but whether reduced macrophage oxidative function causes systemic insulin resistance in vivo is not clear. Here, we show that mice with reduced mitochondrial oxidative phosphorylation (OxPhos) due to myeloid-specific deletion of CR6-interacting factor 1 (Crif1), an essential mitoribosomal factor involved in biogenesis of OxPhos subunits, have M1-like polarization of macrophages and systemic insulin resistance with adipose inflammation. Macrophage GDF15 expression is reduced in mice with impaired oxidative function, but induced upon stimulation with rosiglitazone and IL-4. GDF15 upregulates the oxidative function of macrophages, leading to M2-like polarization, and reverses insulin resistance in ob/ob mice and HFD-fed mice with myeloid-specific deletion of Crif1. Thus, reduced macrophage oxidative function controls systemic insulin resistance and adipose inflammation, which can be reversed with GDF15 and leads to improved oxidative function of macrophages.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleReduced oxidative capacity in macrophages results in systemic insulin resistance-
dc.typeArticle-
dc.identifier.wosid000430389100003-
dc.identifier.scopusid2-s2.0-85045925913-
dc.type.rimsART-
dc.citation.volume9-
dc.citation.publicationnameNATURE COMMUNICATIONS-
dc.identifier.doi10.1038/s41467-018-03998-z-
dc.contributor.localauthorKim, Hail-
dc.contributor.localauthorLee, Heung Kyu-
dc.contributor.localauthorShong, Minho-
dc.contributor.nonIdAuthorJung, Saet-Byel-
dc.contributor.nonIdAuthorChoi, Min Jeong-
dc.contributor.nonIdAuthorRyu, Dongryeol-
dc.contributor.nonIdAuthorYi, Hyon-Seung-
dc.contributor.nonIdAuthorLee, Seong Eun-
dc.contributor.nonIdAuthorChang, Joon Young-
dc.contributor.nonIdAuthorChung, Hyo Kyun-
dc.contributor.nonIdAuthorKim, Yong Kyung-
dc.contributor.nonIdAuthorKang, Seul Gi-
dc.contributor.nonIdAuthorLee, Ju Hee-
dc.contributor.nonIdAuthorKim, Koon Soon-
dc.contributor.nonIdAuthorKim, Hyun Jin-
dc.contributor.nonIdAuthorKim, Cuk-Seong-
dc.contributor.nonIdAuthorLee, Chul-Ho-
dc.contributor.nonIdAuthorWilliams, Robert W.-
dc.contributor.nonIdAuthorAuwerx, Johan-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordPlusDIFFERENTIATION FACTOR 15-
dc.subject.keywordPlusALTERNATIVE ACTIVATION-
dc.subject.keywordPlusADIPOSE-TISSUE-
dc.subject.keywordPlusANOREXIA-CACHEXIA-
dc.subject.keywordPlusGENE-EXPRESSION-
dc.subject.keywordPlusOBESITY-
dc.subject.keywordPlusRECEPTOR-
dc.subject.keywordPlusCYTOKINE-
dc.subject.keywordPlusGDF15-
dc.subject.keywordPlusCELLS-
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