DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Seong-Min | ko |
dc.contributor.author | Lee, Seyeong | ko |
dc.contributor.author | Kim, Dongyoon | ko |
dc.contributor.author | Kang, Dong-Hee | ko |
dc.contributor.author | Yang, Kisuk | ko |
dc.contributor.author | Cho, Seung-Woo | ko |
dc.contributor.author | Lee, Jin Seok | ko |
dc.contributor.author | Choi, Insung S. | ko |
dc.contributor.author | Kang, Kyungtae | ko |
dc.contributor.author | Yoon, Myung-Han | ko |
dc.date.accessioned | 2018-06-16T07:21:56Z | - |
dc.date.available | 2018-06-16T07:21:56Z | - |
dc.date.created | 2018-06-04 | - |
dc.date.created | 2018-06-04 | - |
dc.date.created | 2018-06-04 | - |
dc.date.issued | 2018-05 | - |
dc.identifier.citation | NANO RESEARCH, v.11, no.5, pp.2532 - 2543 | - |
dc.identifier.issn | 1998-0124 | - |
dc.identifier.uri | http://hdl.handle.net/10203/242472 | - |
dc.description.abstract | In this study, we report that height-controlled vertically etched silicon nano-column arrays (vSNAs) induce strong growth cone-to-substrate coupling and accelerate In vitroneurite development while preserving the essential features of initial neurite formation. Large-scale preparation of vSNAs with flat head morphology enabled the generation of well-controlled topographical stimulation without cellular impalement. A systematic analysis on topography-induced variations on cellular morphology and cytoskeletal dynamics was conducted. In addition, neurite development on the grid-patterned vSNAs exhibited preferential adhesion to the nanostructured region and outgrowth directionality. The arrangement of cytoskeletal proteins and the expression of a focal adhesion complex indicated that a strong coupling existed between the underlying nanocolumns and growth cones. Furthermore, the height-controlled nanocolumn substrates differentially modulated neurite polarization and elongation. Our findings provide an important insight into neuron-nanotopography interactions and their role in cell adhesion and neurite development. | - |
dc.language | English | - |
dc.publisher | TSINGHUA UNIV PRESS | - |
dc.title | Strong contact coupling of neuronal growth cones with height-controlled vertical silicon nanocolumns | - |
dc.type | Article | - |
dc.identifier.wosid | 000431999700019 | - |
dc.identifier.scopusid | 2-s2.0-85033405885 | - |
dc.type.rims | ART | - |
dc.citation.volume | 11 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 2532 | - |
dc.citation.endingpage | 2543 | - |
dc.citation.publicationname | NANO RESEARCH | - |
dc.identifier.doi | 10.1007/s12274-017-1878-7 | - |
dc.contributor.localauthor | Choi, Insung S. | - |
dc.contributor.nonIdAuthor | Kim, Seong-Min | - |
dc.contributor.nonIdAuthor | Lee, Seyeong | - |
dc.contributor.nonIdAuthor | Kim, Dongyoon | - |
dc.contributor.nonIdAuthor | Kang, Dong-Hee | - |
dc.contributor.nonIdAuthor | Yang, Kisuk | - |
dc.contributor.nonIdAuthor | Cho, Seung-Woo | - |
dc.contributor.nonIdAuthor | Lee, Jin Seok | - |
dc.contributor.nonIdAuthor | Kang, Kyungtae | - |
dc.contributor.nonIdAuthor | Yoon, Myung-Han | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | vertical silicon nanostructures | - |
dc.subject.keywordAuthor | metal-assisted chemical etching | - |
dc.subject.keywordAuthor | primary hippocampal neurons | - |
dc.subject.keywordAuthor | neurite outgrowth | - |
dc.subject.keywordAuthor | cytoskeletal dynamics | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | N-CADHERIN ADHESIONS | - |
dc.subject.keywordPlus | NEURITE OUTGROWTH | - |
dc.subject.keywordPlus | NANOWIRE ARRAYS | - |
dc.subject.keywordPlus | HIPPOCAMPAL-NEURONS | - |
dc.subject.keywordPlus | CYTOSKELETAL DYNAMICS | - |
dc.subject.keywordPlus | SURFACE-PROPERTIES | - |
dc.subject.keywordPlus | ACTIN FLOW | - |
dc.subject.keywordPlus | GUIDANCE | - |
dc.subject.keywordPlus | TOPOGRAPHY | - |
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