Nano-Protrusive Gold Nanoparticle-Hybridized Polymer Thin Film as a Sensitive, Multipatternable, and Antifouling Biosensor Platform

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Hybrid films consisting of anisotropic octahedral gold nanoparticles (AuNPs) and polymers had their surfaces functionalized and were immobilized on surface plasmon resonance (SPR) sensors for biomolecule detection. Specifically, carboxylated octahedral AuNPs (C-Oh-AuNPs) and poly(allylamine hydrochloride) (PAH) were assembled as ultrathin films by using a layer-by-layer process. The ionic strength generated from the functional groups of C-Oh-AuNP and PAH influenced the composition, its surface morphology, and the reactivity of the film toward further chemical reactions such as the synthesis of spherical AuNPs (S-AuNPs). We were thus able to control the size and the structure of the C-Oh-AuNP and S-AuNPs converted to nano-raspberry-shaped particles. This hierarchical AuNP hybrid film exhibits much more sensitive and stable detection of biomolecules than regular flat chip systems, and this result may be due to the SPR of the AuNP at its surface being able to markedly enhance the local optical field of the chip. The micropatterning of the hybrid coating was also studied by using a soft lithographic patterning method. We, in particular, worked on creating multiplex patterns having different combinations of shapes and fluorescent colors. We expect our hybrid coating system with multicode biomolecular arrays to be used as a powerful platform for biosensor applications.
Publisher
AMER CHEMICAL SOC
Issue Date
2018-04
Language
English
Article Type
Article
Keywords

POLYELECTROLYTE MULTILAYER FILMS; SPUTTER-DEPOSITION; COATINGS; GROWTH; NANOREACTORS; NANOPRISMS; SURFACES; CAPSULES

Citation

ACS APPLIED MATERIALS & INTERFACES, v.10, no.16, pp.13397 - 13405

ISSN
1944-8244
DOI
10.1021/acsami.8b03681
URI
http://hdl.handle.net/10203/242251
Appears in Collection
CH-Journal Papers(저널논문)
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