Ferritin nanocage engineering for development of effective protein-based drug delivery system효과적인 단백질 기반 약물 전달체 개발을 위한 페리틴 나노 케이지 엔지니어링

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dc.contributor.advisorJung, Yongwon-
dc.contributor.advisor정용원-
dc.contributor.authorAhn, Byungjun-
dc.contributor.author안병준-
dc.date.accessioned2018-05-23T19:39:41Z-
dc.date.available2018-05-23T19:39:41Z-
dc.date.issued2017-
dc.identifier.urihttp://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=675886&flag=dissertationen_US
dc.identifier.urihttp://hdl.handle.net/10203/242158-
dc.description학위논문(박사) - 한국과학기술원 : 화학과, 2017.2,[viii, 121 p. :]-
dc.description.abstractProtein-based drug delivery system has been extensively investigated as a safety system. Especially, ferritin nanocage from human origin has been shown no toxicity as using biomaterials. However, because protein generally has its native property related to sophisticated 3D structure, it is very difficult to modify its function as suitable for delivery system without changing outer morphology related to the safety problem. In this paper, we proposed new pH-responsive ferritin delivery carrier through 4-fold channel engineering technics with minimum morphological changes. With changing the 4-fold channel, ferritins have pH-dependent stabilities and unique drug uptake properties. Owing to new function of pH-responsive drug release from 4-fold engineered ferritin, it showed more effective anticancer effects and will be expected to approach new protein-based delivery system methods.-
dc.languageeng-
dc.publisher한국과학기술원-
dc.subjectdrug delivery system-
dc.subjectferritin-
dc.subjectpH-responsive drug release-
dc.subject약물 전달 시스템-
dc.subject페리틴-
dc.subject자극 감응형 약물 방출 시스템-
dc.titleFerritin nanocage engineering for development of effective protein-based drug delivery system-
dc.title.alternative효과적인 단백질 기반 약물 전달체 개발을 위한 페리틴 나노 케이지 엔지니어링-
dc.typeThesis(Ph.D)-
dc.identifier.CNRN325007-
dc.description.department한국과학기술원 :화학과,-
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CH-Theses_Ph.D.(박사논문)
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