DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Jung, Min Whan | - |
dc.contributor.advisor | 정민환 | - |
dc.contributor.author | Kim, Dohoung | - |
dc.contributor.author | 김도형 | - |
dc.date.accessioned | 2018-05-23T19:36:45Z | - |
dc.date.available | 2018-05-23T19:36:45Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=675789&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/241976 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 의과학대학원, 2017.2,[v, 78 p. :] | - |
dc.description.abstract | Inhibitory interneurons are thought to play crucial roles in diverse brain functions. However, specific roles of different inhibitory interneuron subtypes in working memory and outcome processing remain unclear. I found distinct activity patterns and stimulation effects of two major interneuron subtypes, parvalbumin (PV)- and somatostatin (SOM)-expressing interneurons, in the medial prefrontal cortex of mice performing a spatial working memory task or classical conditioning task. PV interneurons showed weak target-dependent delay-period activity. PV interneurons were strongly inhibited by reward and activated by punishment. By contrast, SOM interneurons showed strong target- or cue-dependent delay-period activity and only a subtype of them was inhibited by reward. Furthermore, optogenetic stimulation of PV and SOM interneurons preferentially suppressed discharges of putative pyramidal cells and interneurons, respectively. These results indicate different contributions of PV and SOM interneurons to prefrontal cortical circuit dynamics underlying working memory and outcome processing. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | working memory | - |
dc.subject | outcome processing | - |
dc.subject | interneuron | - |
dc.subject | optogenetics | - |
dc.subject | classical conditioning | - |
dc.subject | 작업기억 | - |
dc.subject | 결과처리 | - |
dc.subject | 사이신경세포 | - |
dc.subject | 광유전학 | - |
dc.subject | 고전적 조건화 | - |
dc.title | Role of prefrontal interneuron in working memory and outcome processing | - |
dc.title.alternative | 작업기억과 결과처리에서 전전두엽 사이신경세포의 역할 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :의과학대학원, | - |
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