Development of a centrifugal force based lab-on-a-chip and its application to biological analysis and chemical synthesis = 원심력 기반의 랩온어칩 시스템 개발 및 생물학적 분석과 화학 합성에의 응용

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Micro-total-analysis-system ($\mu TAS$) or lab-on-a-chip technology is an integrated system that miniaturizes all sequences of lab processes on a single wafer. A number of advantages of $\mu TAS$ including a fast analysis time, reduced reagent consumption, high-throughput and automatic capability, and portability have garnered much attention from the chemical and biological society. Up to now, a variety of microfluidic plat-forms such as pressure or capillary-driven platforms, electro-kinetic operation, and centrifugal-based devices have been developed to realize the integrated $mu TAS$. Among the microfluidic platforms, the centrifugal microfluidic device holds several strengths in term of simple operation by a rotational motor without need of external syringe pumps and microvalves for fluidic manipulation. In addition, fluidic operation units such as valving, mixing, and splitting can be executed by utilizing a sophisticated microfluidic design and centrifugal force, and high degree of symmetry on a single disc allows us to synchronize multiple chemical reactions. In this thesis, four types of novel centrifugal microfluidic devices are presented: two are for the integrated genetic analysis systems and the others are for high-throughput chemical synthesis platforms, while taking full advantages of the rapidity, consistency, integration, and high-throughput capability of centrifugal microfluidics.
Advisors
Seo, Tae Seokresearcher서태석researcher
Description
한국과학기술원 :생명화학공학과,
Publisher
한국과학기술원
Issue Date
2016
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 생명화학공학과, 2016.8,[viii, 149 p. :]

Keywords

Centrifugal microfluidics; Nucleic acid test; Point-of-care-diagnostics; High-throughput screening; Microreactors; 원심력마이크로플루이딕스; 유전자 검사; 현장유전자진단; 고속대량스크리닝; 마이크로리액터

URI
http://hdl.handle.net/10203/241867
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=669278&flag=dissertation
Appears in Collection
CBE-Theses_Ph.D.(박사논문)
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