DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lie, Eunkyung | ko |
dc.contributor.author | Li, Yan | ko |
dc.contributor.author | Kim, Ryunhee | ko |
dc.contributor.author | Kim, Eunjoon | ko |
dc.date.accessioned | 2018-04-24T06:32:47Z | - |
dc.date.available | 2018-04-24T06:32:47Z | - |
dc.date.created | 2018-04-18 | - |
dc.date.created | 2018-04-18 | - |
dc.date.created | 2018-04-18 | - |
dc.date.created | 2018-04-18 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.citation | FRONTIERS IN MOLECULAR NEUROSCIENCE, v.11 | - |
dc.identifier.issn | 1662-5099 | - |
dc.identifier.uri | http://hdl.handle.net/10203/241409 | - |
dc.description.abstract | Synaptic adhesion-like molecules (SALMs) are a family of cell adhesion molecules involved in regulating neuronal and synapse development that have also been implicated in diverse brain dysfunctions, including autism spectrum disorders (ASDs). SALMs, also known as leucine-rich repeat (LRR) and fibronectin III domain-containing (LRFN) proteins, were originally identified as a group of novel adhesion-like molecules that contain LRRs in the extracellular region as well as a PDZ domain-binding tail that couples to PSD-95, an abundant excitatory postsynaptic scaffolding protein. While studies over the last decade have steadily explored the basic properties and synaptic and neuronal functions of SALMs, a number of recent studies have provided novel insights into molecular, structural, functional and clinical aspects of SALMs. Here we summarize these findings and discuss how SALMs act in concert with other synaptic proteins to regulate synapse development and function. | - |
dc.language | English | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.subject | PROTEIN-TYROSINE-PHOSPHATASE | - |
dc.subject | ACTIN CYTOSKELETON REORGANIZATION | - |
dc.subject | POSTSYNAPTIC DENSITY PROTEINS | - |
dc.subject | AUTISM SPECTRUM DISORDERS | - |
dc.subject | EXCITATORY SYNAPSES | - |
dc.subject | PTP-SIGMA | - |
dc.subject | TRANSSYNAPTIC INTERACTION | - |
dc.subject | INTELLECTUAL DISABILITY | - |
dc.subject | GLUTAMATE RECEPTORS | - |
dc.subject | HIPPOCAMPAL-NEURONS | - |
dc.title | SALM/Lrfn Family Synaptic Adhesion Molecules | - |
dc.type | Article | - |
dc.identifier.wosid | 000429259400001 | - |
dc.identifier.scopusid | 2-s2.0-85046884906 | - |
dc.type.rims | ART | - |
dc.citation.volume | 11 | - |
dc.citation.publicationname | FRONTIERS IN MOLECULAR NEUROSCIENCE | - |
dc.identifier.doi | 10.3389/fnmol.2018.00105 | - |
dc.contributor.localauthor | Kim, Eunjoon | - |
dc.contributor.nonIdAuthor | Lie, Eunkyung | - |
dc.contributor.nonIdAuthor | Li, Yan | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Review | - |
dc.subject.keywordAuthor | adhesion molecules | - |
dc.subject.keywordAuthor | synaptic | - |
dc.subject.keywordAuthor | SALM | - |
dc.subject.keywordAuthor | Lrfn | - |
dc.subject.keywordAuthor | PSD-95 | - |
dc.subject.keywordAuthor | adhesion molecules | - |
dc.subject.keywordAuthor | synaptic | - |
dc.subject.keywordAuthor | SALM | - |
dc.subject.keywordAuthor | Lrfn | - |
dc.subject.keywordAuthor | PSD-95 | - |
dc.subject.keywordPlus | PROTEIN-TYROSINE-PHOSPHATASE | - |
dc.subject.keywordPlus | ACTIN CYTOSKELETON REORGANIZATION | - |
dc.subject.keywordPlus | POSTSYNAPTIC DENSITY PROTEINS | - |
dc.subject.keywordPlus | AUTISM SPECTRUM DISORDERS | - |
dc.subject.keywordPlus | EXCITATORY SYNAPSES | - |
dc.subject.keywordPlus | PTP-SIGMA | - |
dc.subject.keywordPlus | TRANSSYNAPTIC INTERACTION | - |
dc.subject.keywordPlus | INTELLECTUAL DISABILITY | - |
dc.subject.keywordPlus | GLUTAMATE RECEPTORS | - |
dc.subject.keywordPlus | HIPPOCAMPAL-NEURONS | - |
dc.subject.keywordPlus | PROTEIN-TYROSINE-PHOSPHATASE | - |
dc.subject.keywordPlus | ACTIN CYTOSKELETON REORGANIZATION | - |
dc.subject.keywordPlus | POSTSYNAPTIC DENSITY PROTEINS | - |
dc.subject.keywordPlus | AUTISM SPECTRUM DISORDERS | - |
dc.subject.keywordPlus | EXCITATORY SYNAPSES | - |
dc.subject.keywordPlus | PTP-SIGMA | - |
dc.subject.keywordPlus | TRANSSYNAPTIC INTERACTION | - |
dc.subject.keywordPlus | INTELLECTUAL DISABILITY | - |
dc.subject.keywordPlus | GLUTAMATE RECEPTORS | - |
dc.subject.keywordPlus | HIPPOCAMPAL-NEURONS | - |
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