The ins and outs of G protein-coupled receptor trafficking

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All cells are faced with the complexity of converting a myriad of extracellular stimuli to intracellular signals and appropriate biological responses. This process involves a series of highly orchestrated molecular events, many of which occur at the plasma-membrane interface. Endocytosis is one such event, and functions to transport numerous small molecules and protein cargo. For G protein-coupled receptors (GPCRs), endocytosis serves as a mechanism to regulate cell-surface-receptor levels, thereby, contributing to the regulation of hormonal responsiveness. The trafficking of GPCRs through the endocytic pathway involves three main steps: recruitment of receptors to discrete endocytic sites, internalization and intracellular sorting. Many recent studies have advanced our understanding of these steps. Novel mechanistic insight into the recruitment of GPCRs to sites of endocytosis has been gained and the discovery of novel protein-protein interactions, which define more clearly the processes of internalization and endocytic sorting, have been characterized. In addition, a role for ubiquitin in internalization and sorting to the degradative pathway has emerged.
Publisher
ELSEVIER SCIENCE LONDON
Issue Date
2003-07
Language
English
Article Type
Review
Keywords

CLATHRIN-COATED PITS; LUTEINIZING HORMONE/CHORIOGONADOTROPIN RECEPTOR; AGONIST-INDUCED INTERNALIZATION; KINASE-C ACTIVATION; BETA-ARRESTIN; BETA(2)-ADRENERGIC RECEPTOR; BETA-2-ADRENERGIC RECEPTOR; STIMULATED ENDOCYTOSIS; TONIC INTERNALIZATION; MEDIATED ENDOCYTOSIS

Citation

TRENDS IN BIOCHEMICAL SCIENCES, v.28, no.7, pp.369 - 376

ISSN
0968-0004
DOI
10.1016/S0968-0004(03)00134-8
URI
http://hdl.handle.net/10203/240869
Appears in Collection
MSE-Journal Papers(저널논문)
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