DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bertho, N | ko |
dc.contributor.author | Cerny, J | ko |
dc.contributor.author | Kim, You-Me | ko |
dc.contributor.author | Fiebiger, E | ko |
dc.contributor.author | Ploegh, H | ko |
dc.contributor.author | Boes, M | ko |
dc.date.accessioned | 2018-03-21T02:57:38Z | - |
dc.date.available | 2018-03-21T02:57:38Z | - |
dc.date.created | 2018-03-14 | - |
dc.date.created | 2018-03-14 | - |
dc.date.issued | 2003-12 | - |
dc.identifier.citation | JOURNAL OF IMMUNOLOGY, v.171, no.11, pp.5689 - 5696 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | http://hdl.handle.net/10203/240868 | - |
dc.description.abstract | Activation of naive CD4 T cells by dendritic cells requires the sequential interaction of many TCR molecules with peptide-class II complexes of the appropriate specificity. Such interaction results in morphological transformation of class II MHC-containing endosomal compartments. In this study, we analyze the requirements for long tubular endosomal structures that polarize toward T cell contact sites using dendritic cells from I-A(b) class II-enhanced green fluorescent protein knock-in mice and I-A(b)-restricted CD4 T cells specific for OVA. Clustering of membrane proteins and ligation of T cell adhesion molecules LFA-1 and CD2 are involved in induction of endosomal tubulation. Activation of T cells increases their ability to induce class II-enhanced green fluorescent protein-positive tubules in dendritic cells, in part through up-regulation of CD40 ligand. Remarkably, and in stark contrast with the result obtained with dendritic cells loaded with intact OVA, OVA peptide added to dendritic cells failed to evoke T cell-polarized endosomal tubulation even though both conditions allowed T cell stimulation. These results suggest the existence of microdomains on the membrane of dendritic cells that allow Ag-speeific T cells to evoke tubulation in the dendritic cell. | - |
dc.language | English | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.subject | ANTIGEN PRESENTATION | - |
dc.subject | IMMUNOLOGICAL SYNAPSE | - |
dc.subject | TETRASPAN MICRODOMAINS | - |
dc.subject | ACTIVATION | - |
dc.subject | TRANSPORT | - |
dc.subject | MOLECULES | - |
dc.subject | COMPLEXES | - |
dc.subject | CYTOSKELETON | - |
dc.subject | EXPRESSION | - |
dc.subject | CDW78 | - |
dc.title | Requirements for T cell-polarized tubulation of class II+ compartments in dendritic cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000186767200009 | - |
dc.identifier.scopusid | 2-s2.0-0344153938 | - |
dc.type.rims | ART | - |
dc.citation.volume | 171 | - |
dc.citation.issue | 11 | - |
dc.citation.beginningpage | 5689 | - |
dc.citation.endingpage | 5696 | - |
dc.citation.publicationname | JOURNAL OF IMMUNOLOGY | - |
dc.identifier.doi | 10.4049/jimmunol.171.11.5689 | - |
dc.contributor.localauthor | Kim, You-Me | - |
dc.contributor.nonIdAuthor | Bertho, N | - |
dc.contributor.nonIdAuthor | Cerny, J | - |
dc.contributor.nonIdAuthor | Fiebiger, E | - |
dc.contributor.nonIdAuthor | Ploegh, H | - |
dc.contributor.nonIdAuthor | Boes, M | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ANTIGEN PRESENTATION | - |
dc.subject.keywordPlus | IMMUNOLOGICAL SYNAPSE | - |
dc.subject.keywordPlus | TETRASPAN MICRODOMAINS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | TRANSPORT | - |
dc.subject.keywordPlus | MOLECULES | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | CYTOSKELETON | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CDW78 | - |
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