Increased prevalence of white matter hyperintensities in patients with panic disorder

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The aim of the current study is to compare the prevalence, severity and location of cerebral white matter hyperintensities (WMH) between patients with panic disorder (PD) and healthy control subjects. Patients with PD (n = 24) and matched healthy control subjects (n = 24) were scanned using a 3.0 Tesla whole-body magnetic resonance scanner. Axial T2-weighted and fluid-attenuated inversion recovery images were acquired and evaluated for the prevalence, severity and location of WMH using the modified composite scale of Fazekas and Coffey and coded separately for deep and periventricular WMH. Logistic regression analyses were used to assess the association between WMH and the diagnosis of PD. A greater severity of total WMH was associated with a diagnosis of PD in a dose-dependent pattern (odds ratio [OR] = 8.8, P = 0.005 for mild WMH; OR = 27.7, P = 0.007 for moderate to severe WMH). Deep WMH, where most group differences originated, were predominantly located in the frontal region of the brain (n = 16 in PD, n = 1 in control). The current report is the first study to report an increased prevalence of WMH in patients with PD.
Publisher
SAGE PUBLICATIONS LTD
Issue Date
2010-05
Language
English
Article Type
Article
Keywords

MAJOR DEPRESSIVE DISORDER; CEREBRAL-BLOOD-FLOW; SUBCORTICAL HYPERINTENSITIES; BIPOLAR DISORDER; LATE-LIFE; PSYCHIATRIC-DISORDERS; ANXIETY DISORDERS; FEAR EXTINCTION; BASAL GANGLIA; RISK-FACTORS

Citation

JOURNAL OF PSYCHOPHARMACOLOGY, v.24, no.5, pp.717 - 723

ISSN
0269-8811
DOI
10.1177/0269881108098476
URI
http://hdl.handle.net/10203/240185
Appears in Collection
GCT-Journal Papers(저널논문)
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