Biomimetic strategies for the glioblastoma microenvironment

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Glioblastoma multiforme (GBM) is a devastating type of tumor with high mortality, caused by extensive infiltration into adjacent tissue and rapid recurrence. Most therapies for GBM have focused on the cytotoxicity and have not targeted GBM spread. However, there have been numerous attempts to improve therapy by addressing GBM invasion, through understanding and mimicking its behavior using three-dimensional (3D) experimental models. Compared with two-dimensional models and in vivo animal models, 3D GBM models can capture the invasive motility of glioma cells within a 3D environment comprising many cellular and non-cellular components. Based on tissue engineering techniques, GBM invasion has been investigated within a biologically relevant environment, from biophysical and biochemical perspectives, to clarify the pro-invasive factors of GBM. This review discusses the recent progress in techniques for modeling the microenvironments of GBM tissue and suggests future directions with respect to recreating the GBM microenvironment and preclinical applications.
Publisher
FRONTIERS MEDIA SA
Issue Date
2017-12
Language
English
Article Type
Review
Keywords

GLIOMA-CELL INVASION; BRAIN EXTRACELLULAR-MATRIX; HYALURONIC-ACID HYDROGEL; PEG-BASED HYDROGELS; PSEUDOPALISADING NECROSIS; ELECTROSPUN NANOFIBERS; CHONDROITIN SULFATE; MALIGNANT GLIOMAS; CANCER INVASION; MIGRATION

Citation

Frontiers in Materials, v.4

ISSN
2296-8016
DOI
10.3389/fmats.2017.00045
URI
http://hdl.handle.net/10203/240043
Appears in Collection
BiS-Journal Papers(저널논문)
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