DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, So Yeon | ko |
dc.contributor.author | Jeong, Jong-Min | ko |
dc.contributor.author | Kim, Soo Jin | ko |
dc.contributor.author | Seo, Wonhyo | ko |
dc.contributor.author | Kim, Myung-Ho | ko |
dc.contributor.author | Choi, Won-Mook | ko |
dc.contributor.author | Yoo, Wonbeak | ko |
dc.contributor.author | Lee, Jun-Hee | ko |
dc.contributor.author | Shim, Young Ri | ko |
dc.contributor.author | Yi, Hyon-Seung | ko |
dc.contributor.author | Lee, Young Sun | ko |
dc.contributor.author | Eun, Hyuk Soo | ko |
dc.contributor.author | Lee, Byung Seok | ko |
dc.contributor.author | Chun, Kwangsik | ko |
dc.contributor.author | Kang, Suk-Jo | ko |
dc.contributor.author | Kim, Sun Chang | ko |
dc.contributor.author | Gao, B | ko |
dc.contributor.author | Kunos, G | ko |
dc.contributor.author | Kim, Ho Min | ko |
dc.contributor.author | Jeong, Won-Il | ko |
dc.date.accessioned | 2018-02-21T05:10:08Z | - |
dc.date.available | 2018-02-21T05:10:08Z | - |
dc.date.created | 2017-12-20 | - |
dc.date.created | 2017-12-20 | - |
dc.date.created | 2017-12-20 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v.8, pp.1 - 15 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10203/239945 | - |
dc.description.abstract | Reactive oxygen species (ROS) contribute to the development of non-alcoholic fatty liver disease. ROS generation by infiltrating macrophages involves multiple mechanisms, including Toll-like receptor 4 (TLR4)-mediated NADPH oxidase (NOX) activation. Here, we show that palmitate-stimulated CD11b+F4/80low hepatic infiltrating macrophages, but not CD11b+F4/80high Kupffer cells, generate ROS via dynamin-mediated endocytosis of TLR4 and NOX2, independently from MyD88 and TRIF. We demonstrate that differently from LPS-mediated dimerization of the TLR4–MD2 complex, palmitate binds a monomeric TLR4–MD2 complex that triggers endocytosis, ROS generation and increases pro-interleukin-1β expression in macrophages. Palmitate-induced ROS generation in human CD68lowCD14high macrophages is strongly suppressed by inhibition of dynamin. Furthermore, Nox2-deficient mice are protected against high-fat diet-induced hepatic steatosis and insulin resistance. Therefore, endocytosis of TLR4 and NOX2 into macrophages might be a novel therapeutic target for non-alcoholic fatty liver disease. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | HIGH-FAT DIET | - |
dc.subject | REACTIVE OXYGEN | - |
dc.subject | NLRP3 INFLAMMASOME | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | RECEPTOR 4 | - |
dc.subject | ISOLATION STRESS | - |
dc.subject | ADIPOSE-TISSUE | - |
dc.subject | NOX FAMILY | - |
dc.subject | ACTIVATION | - |
dc.subject | MICE | - |
dc.title | Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4-MD2 complex | - |
dc.type | Article | - |
dc.identifier.wosid | 000418567200014 | - |
dc.identifier.scopusid | 2-s2.0-85042357204 | - |
dc.type.rims | ART | - |
dc.citation.volume | 8 | - |
dc.citation.beginningpage | 1 | - |
dc.citation.endingpage | 15 | - |
dc.citation.publicationname | NATURE COMMUNICATIONS | - |
dc.identifier.doi | 10.1038/s41467-017-02325-2 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Kang, Suk-Jo | - |
dc.contributor.localauthor | Kim, Sun Chang | - |
dc.contributor.localauthor | Kim, Ho Min | - |
dc.contributor.localauthor | Jeong, Won-Il | - |
dc.contributor.nonIdAuthor | Yoo, Wonbeak | - |
dc.contributor.nonIdAuthor | Yi, Hyon-Seung | - |
dc.contributor.nonIdAuthor | Lee, Young Sun | - |
dc.contributor.nonIdAuthor | Eun, Hyuk Soo | - |
dc.contributor.nonIdAuthor | Lee, Byung Seok | - |
dc.contributor.nonIdAuthor | Chun, Kwangsik | - |
dc.contributor.nonIdAuthor | Gao, B | - |
dc.contributor.nonIdAuthor | Kunos, G | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | HIGH-FAT DIET | - |
dc.subject.keywordPlus | REACTIVE OXYGEN | - |
dc.subject.keywordPlus | NLRP3 INFLAMMASOME | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | RECEPTOR 4 | - |
dc.subject.keywordPlus | ISOLATION STRESS | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | NOX FAMILY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MICE | - |
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