DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Byoung-Hoon | ko |
dc.contributor.author | Park, Moonseong | ko |
dc.contributor.author | Jeong, Ki-Hun | ko |
dc.date.accessioned | 2018-02-21T05:08:56Z | - |
dc.date.available | 2018-02-21T05:08:56Z | - |
dc.date.created | 2018-01-22 | - |
dc.date.created | 2018-01-22 | - |
dc.date.created | 2018-01-22 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.citation | BIOCHIP JOURNAL, v.11, no.4, pp.294 - 299 | - |
dc.identifier.issn | 1976-0280 | - |
dc.identifier.uri | http://hdl.handle.net/10203/239926 | - |
dc.description.abstract | Human tears have attracted attention with easy-accessible indicators of healthcare monitoring. Recently self-monitoring of tear glucose in place of blood glucose has been developed with microfluidic paper-based analysis for a non-invasive diagnosis of diabetes. However, most previous works still have many limitations in unstable sample collection, low sensitivity, and insufficient sample volume. Here, we report a colorimetric Schirmer strip with preconcentration for tear glucose detection. A wax barrier on a paper strip enables tear collection of a fixed quantity as well as biocompatible incorporation of tear collection and detection by preventing flow reversal of reagents. Additional solvent was injected on a sampling site after tear collection, which accumulates the dispersed glucose into active site by capillary-driven flow for signal amplification. Glucose concentration was quantitatively detected at 0.1-2 mM by using a simple colorimetric method without any further image processing. The color changes in glucose concentration were clearly distinguishable between normal and diabetic patient-level. The colorimetric paper strip allows straightforward sensing platform for noninvasive diagnosis of diabetes and direct application of paper-based technology to the human body fluids. | - |
dc.language | English | - |
dc.publisher | KOREAN BIOCHIP SOCIETY-KBCS | - |
dc.title | Colorimetric Schirmer Strip for Tear Glucose Detection | - |
dc.type | Article | - |
dc.identifier.wosid | 000419485600005 | - |
dc.identifier.scopusid | 2-s2.0-85040122897 | - |
dc.type.rims | ART | - |
dc.citation.volume | 11 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 294 | - |
dc.citation.endingpage | 299 | - |
dc.citation.publicationname | BIOCHIP JOURNAL | - |
dc.identifier.doi | 10.1007/s13206-017-1405-7 | - |
dc.contributor.localauthor | Jeong, Ki-Hun | - |
dc.contributor.nonIdAuthor | Kang, Byoung-Hoon | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Tear glucose | - |
dc.subject.keywordAuthor | Paper microfluidics | - |
dc.subject.keywordAuthor | Preconcentration | - |
dc.subject.keywordAuthor | Schirmer strip | - |
dc.subject.keywordAuthor | Diabetes diagnosis | - |
dc.subject.keywordPlus | MICROFLUIDIC DEVICES | - |
dc.subject.keywordPlus | BLOOD-GLUCOSE | - |
dc.subject.keywordPlus | PAPER | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | IMMUNOASSAY | - |
dc.subject.keywordPlus | SENSORS | - |
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