Systems biology has been changing the way biological and biotechnological research is performed. Now, systems biological approaches can be taken to develop bioprocesses for the production of valuable drugs, commodity and fine chemicals, fuels, and polymers and other materials; this is termed systems biotechnology. Here I present the general strategies for systems biotechnology and several examples of applying systems biotechnological strategies for the development of bioprocesses for the efficient production of chemicals and materials. This also includes a strategy of systems metabolic engineering for the development of microbial strains. It is expected that systems biotechnology will be at the heart of successful industrial biotechnology towards low carbon green growth of the world.