DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서린 | ko |
dc.contributor.author | 김재훈 | ko |
dc.date.accessioned | 2018-01-22T02:12:29Z | - |
dc.date.available | 2018-01-22T02:12:29Z | - |
dc.date.created | 2017-12-21 | - |
dc.date.issued | 2017-12-13 | - |
dc.identifier.citation | 2017년 한국분자세포생물학회 에피유전체학분과 심포지움 | - |
dc.identifier.uri | http://hdl.handle.net/10203/237241 | - |
dc.description.abstract | Polycomb repressive complex 1 (PRC1) plays important roles in regulating developmental genes and maintaining the embryonic stem cells (ESCs) identity. PRC1 complex has many variants, however, it is not known how and where these variants are recruited to their lineage-specific genes. Here, we show that the transcription factor Kruppel-like factor 2 (Klf2) recruits Ring1b which is PRC1 enzymatic subunit and interacts directly in ESCs. Klf2 and Ring1b repress endoderm relating genes and downregulation of Klf2 and Ring1b causes endoderm differentiation of mouse ESCs. Thus, our study reveals that pluripotency has highly delicative repression mechanism controlled by recruitment of PRC1 complex through Klf2, and also demonstrates a important function of Klf2 in endoderm specific gene expression. | - |
dc.language | English | - |
dc.publisher | 한국분자세포생물학회 | - |
dc.title | Regulation mechanism of pluripotency through interaction of Klf2 and PRC1 complex in mESCs | - |
dc.type | Conference | - |
dc.type.rims | CONF | - |
dc.citation.publicationname | 2017년 한국분자세포생물학회 에피유전체학분과 심포지움 | - |
dc.identifier.conferencecountry | KO | - |
dc.identifier.conferencelocation | 강원도 홍천 대명리조트 소노펠리체 타워센터 3층 | - |
dc.contributor.localauthor | 김재훈 | - |
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