METHOD OF INDUCING DIFFERENTIATION OF EMBRYONIC STEM CELLS INTO HEMANGIOBLAST인간배아줄기세포의 신호전달체계 조절을 통한 혈관모세포 (hemangioblast)로의 분화유도 방법

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The present invention relates to a composition for inducing embryonic stem cell differentiation comprising a MEK/ERK (mitogen-activated protein kinase kinase/extracellular regulated kinase) signal transduction inhibitor and BMP (bone morphogenetic protein), and a method for inducing differentiation of embryonic stem cells into mesodermal cells using the same. Further, the mesodermal cells obtained by the above method are able to differentiate into various mesenchymal tissue cells. In particular, the present invention relates to a method for inducing differentiation into hemangioblast by culturing the mesodermal cells obtained by the above method in the presence of VEGF (vascular endothelial cell growth factor) and bFGF (basic fibroblast growth factor). The differentiated hemangioblasts can be further differentiated into vascular endothelial cells, vascular smooth muscle cells, and hematopoietic stem cells under various culture conditions.
Assignee
KAIST
Country
US (United States)
Issue Date
2013-08-13
Application Date
2010-08-18
Application Number
12858747
Registration Date
2013-08-13
Registration Number
8,507,275
URI
http://hdl.handle.net/10203/233857
Appears in Collection
BS-Patent(특허)
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