Method for mass production of antimicrobial peptide

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The present invention provides a method for mass production of an antimicrobial peptide, which comprises the steps of: constructing a fusion gene containing a first gene encoding a negatively charged acidic peptide having at least two cysteine residues and a second gene encoding a positively charged basic antimicrobial peptide; transforming a host microorganism with an expression vector comprising the fusion gene; cultivating the transformed microorganism to express a fusion peptide containing the acidic peptide and antimicrobial peptide, and, recovering the expressed antimicrobial peptide. In accordance with the present invention, the inhibitory effect of the expressed antimicrobial peptide on the growth of the host microorganism can be dramatically minimized by fusing it with the acidic peptide. Accordingly, antimicrobial peptides can be produced massively from a recombinant microorganism regardless of the kind of the antimicrobial peptides.
Assignee
Samyang Genex Corporation, KAIST
Country
US (United States)
Issue Date
2001-02-06
Application Date
1999-03-10
Application Number
09230180
Registration Date
2001-02-06
Registration Number
6183992
URI
http://hdl.handle.net/10203/233806
Appears in Collection
BS-Patent(특허)
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