Inhibition of apoptosis by the expression of antisense RNA of caspase-3카스파제-3에 대한 안티센스 뉴클레오타이드, 그의 발현 벡터 및 이를 이용한 세포예정사의 억제방법

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The present invention relates to an antisense nucleotide of caspase-3, an expression vector encoding antisense RNA of caspase-3, and an inhibition method of cellular apoptosis in recombinant Chinese hamster ovary (CHO) cells using the same. More precisely, the present invention relates to an antisense nucleotide composed of a base sequence represented by Sequence ID No. 1, which suppresses the expression of caspase-3, an expression vector containing the above antisense nucleotide and expressing antisense RNA of caspase-3, and an inhibition method of apoptosis of recombinant cells by suppressing the expression of caspase-3 through introducing the above expression vector into the recombinant cells and then expressing antisense RNA of caspase-3. According to the present invention, apoptosis can be inhibited by suppressing the activation of caspase-3, which is related to the apoptosis, and the integrity of target protein produced in the recombinant cells can be enhanced.
Assignee
KAIST
Country
US (United States)
Issue Date
2005-09-13
Application Date
2002-09-17
Application Number
10245813
Registration Date
2005-09-13
Registration Number
6943022
URI
http://hdl.handle.net/10203/233726
Appears in Collection
BS-Patent(특허)
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