Screening of drug for attention deficit hyperactive disorder by using GIT1 knock-out mice as a novel ADHD mouse modelGIT1유전자 결손 형질전환 마우스 및 이를 이용한 약물 스크리닝 방법

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 191
  • Download : 0
Provided is a method of using any mammal except humans, in particular, a mammal as an attention deficit hyperactivity disorder model, wherein genes of G protein-coupled receptor kinase interacting protein 1 (GIT1) as a neuronal synapse protein in the brain are knocked out from the mammal. In addition, disclosed is analysis of GIT1 knock-out mice in aspects of molecular biology, cellular biology, electrical biology and animal behavior and, more particularly, a screening method of novel drug, wherein excessive behavior as an attention deficit hyperactive disorder as well as recovery of theta wave in the frontal lobe are observed by administering a candidate material of the drug, thereby inducing recovery of the attention deficit hyperactivity disorder.
Assignee
KAIST
Country
US (United States)
Issue Date
2013-10-08
Application Date
2012-04-13
Application Number
13446789
Registration Date
2013-10-08
Registration Number
8,552,253
URI
http://hdl.handle.net/10203/230535
Appears in Collection
BS-Patent(특허)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0