SIRNA-HYDROPHILIC POLYMER CONJUGATES AND PROCESS OF PREPARATION THEREOFsiRNA와 친수성 고분자 접합체를 이용한 siRNA의 세포내 전달체 및 그의 제조방법

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Disclosed are hybrid conjugates formed by covalently bonding siRNA (small interfering RNA) molecules to hydrophilic polymers for improving stability of the siRNA molecules effective for gene therapy in vivo, and polyelectrolyte complex micelles formed by ionic interactions between the conjugates and multifunctional cationic compounds. The siRNA-hydrophilic polymer conjugates and polyelectrolyte complex micelles derived therefrom can be advantageously used for improving stability of the siRNA molecules in vivo. Consequently, the delivery of siRNA molecules for therapeutic applications into cells can be facilitated, and the siRNA is still active even though a small dose of the siRNA is used.
Assignee
KAIST, BIONEER CORP, SAMYANG CORP
Country
CN (China)
Issue Date
2014-02-04
Application Date
2008-02-15
Application Number
2619533
Registration Date
2014-02-04
Registration Number
2619533
URI
http://hdl.handle.net/10203/229790
Appears in Collection
BS-Patent(특허)
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