Recent advances in systems metabolic engineering tools and strategies

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Metabolic engineering has been playing increasingly important roles in developing microbial cell factories for the production of various chemicals and materials to achieve sustainable chemical industry. Nowadays, many tools and strategies are available for performing systems metabolic engineering that allows systems-level metabolic engineering in more sophisticated and diverse ways by adopting rapidly advancing methodologies and tools of systems biology, synthetic biology and evolutionary engineering. As an outcome, development of more efficient microbial cell factories has become possible. Here, we review recent advances in systems metabolic engineering tools and strategies together with accompanying application examples. In addition, we describe how these tools and strategies work together in simultaneous and synergistic ways to develop novel microbial cell factories.
Publisher
CURRENT BIOLOGY LTD
Issue Date
2017-10
Language
English
Article Type
Review
Citation

CURRENT OPINION IN BIOTECHNOLOGY, v.47, pp.67 - 82

ISSN
0958-1669
DOI
10.1016/j.copbio.2017.06.007
URI
http://hdl.handle.net/10203/227065
Appears in Collection
CBE-Journal Papers(저널논문)
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