The Ino80 complex mediates epigenetic centromere propagation via active removal of histone H3

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dc.contributor.authorChoi, Eun Shikko
dc.contributor.authorCheon, Youngseoko
dc.contributor.authorKang, Keunsooko
dc.contributor.authorLee, Daeyoupko
dc.date.accessioned2017-10-23T01:27:08Z-
dc.date.available2017-10-23T01:27:08Z-
dc.date.created2017-09-25-
dc.date.created2017-09-25-
dc.date.issued2017-09-
dc.identifier.citationNATURE COMMUNICATIONS, v.8-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10203/226284-
dc.description.abstractThe centromere is the chromosomal locus at which the kinetochore is assembled to direct chromosome segregation. The histone H3 variant, centromere protein A (CENP-A), is known to epigenetically mark active centromeres, but the mechanism by which CENP-A propagates at the centromere, replacing histone H3, remains poorly understood. Using fission yeast, here we show that the Ino80 adenosine triphosphate (ATP)-dependent chromatin-remodeling complex, which removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. CENP-ACnp1 chromatin actively recruits the Ino80 complex to centromeres to elicit eviction of histone H3-containing nucleosomes. Artificial targeting of Ino80 subunits to a non-centromeric DNA sequence placed in a native centromere enhances the spreading of CENP-ACnp1 chromatin into the non-centromeric DNA. Based on these results, we propose that CENP-ACnp1 chromatin employs the Ino80 complex to mediate the replacement of histone H3 with CENP-ACnp1, and thereby reinforces itself.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.subjectCHROMATIN REMODELING COMPLEX-
dc.subjectCENP-A CHROMATIN-
dc.subjectFISSION YEAST CENTROMERES-
dc.subjectIN-VIVO-
dc.subjectNUCLEOSOMES-
dc.subjectCHROMOSOME-
dc.subjectPROTEIN-
dc.subjectHJURP-
dc.subjectSCM3-
dc.subjectDEPOSITION-
dc.titleThe Ino80 complex mediates epigenetic centromere propagation via active removal of histone H3-
dc.typeArticle-
dc.identifier.wosid000410709900005-
dc.identifier.scopusid2-s2.0-85029325967-
dc.type.rimsART-
dc.citation.volume8-
dc.citation.publicationnameNATURE COMMUNICATIONS-
dc.identifier.doi10.1038/s41467-017-00704-3-
dc.contributor.localauthorLee, Daeyoup-
dc.contributor.nonIdAuthorChoi, Eun Shik-
dc.contributor.nonIdAuthorKang, Keunsoo-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordPlusCHROMATIN REMODELING COMPLEX-
dc.subject.keywordPlusCENP-A CHROMATIN-
dc.subject.keywordPlusFISSION YEAST CENTROMERES-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusNUCLEOSOMES-
dc.subject.keywordPlusCHROMOSOME-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordPlusHJURP-
dc.subject.keywordPlusSCM3-
dc.subject.keywordPlusDEPOSITION-
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