DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Eun Shik | ko |
dc.contributor.author | Cheon, Youngseo | ko |
dc.contributor.author | Kang, Keunsoo | ko |
dc.contributor.author | Lee, Daeyoup | ko |
dc.date.accessioned | 2017-10-23T01:27:08Z | - |
dc.date.available | 2017-10-23T01:27:08Z | - |
dc.date.created | 2017-09-25 | - |
dc.date.created | 2017-09-25 | - |
dc.date.created | 2017-09-25 | - |
dc.date.issued | 2017-09 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v.8 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10203/226284 | - |
dc.description.abstract | The centromere is the chromosomal locus at which the kinetochore is assembled to direct chromosome segregation. The histone H3 variant, centromere protein A (CENP-A), is known to epigenetically mark active centromeres, but the mechanism by which CENP-A propagates at the centromere, replacing histone H3, remains poorly understood. Using fission yeast, here we show that the Ino80 adenosine triphosphate (ATP)-dependent chromatin-remodeling complex, which removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. CENP-ACnp1 chromatin actively recruits the Ino80 complex to centromeres to elicit eviction of histone H3-containing nucleosomes. Artificial targeting of Ino80 subunits to a non-centromeric DNA sequence placed in a native centromere enhances the spreading of CENP-ACnp1 chromatin into the non-centromeric DNA. Based on these results, we propose that CENP-ACnp1 chromatin employs the Ino80 complex to mediate the replacement of histone H3 with CENP-ACnp1, and thereby reinforces itself. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | The Ino80 complex mediates epigenetic centromere propagation via active removal of histone H3 | - |
dc.type | Article | - |
dc.identifier.wosid | 000410709900005 | - |
dc.identifier.scopusid | 2-s2.0-85029325967 | - |
dc.type.rims | ART | - |
dc.citation.volume | 8 | - |
dc.citation.publicationname | NATURE COMMUNICATIONS | - |
dc.identifier.doi | 10.1038/s41467-017-00704-3 | - |
dc.contributor.localauthor | Lee, Daeyoup | - |
dc.contributor.nonIdAuthor | Choi, Eun Shik | - |
dc.contributor.nonIdAuthor | Kang, Keunsoo | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | CHROMATIN REMODELING COMPLEX | - |
dc.subject.keywordPlus | CENP-A CHROMATIN | - |
dc.subject.keywordPlus | FISSION YEAST CENTROMERES | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | NUCLEOSOMES | - |
dc.subject.keywordPlus | CHROMOSOME | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | HJURP | - |
dc.subject.keywordPlus | SCM3 | - |
dc.subject.keywordPlus | DEPOSITION | - |
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