EXPANSION OF IMMUNOSENESCENT T CELL FRACTION IN CHRONIC KIDNEY DISEASE PATIENTS: EXPLORING NEW PATHOGENIC MECHANISMS OF INCREASED ARTERIAL STIFFNESS

Abstract

Objective: Chronic kidney disease (CKD) is associated with increased arterial stiffness, which is a well-known predictor of future cardiovascular events. However, the underlying mechanism of arterial stiffening in CKD is not well known. Accelerated immune aging, characterized by expansion of immunosenescent T cell fraction might be involved in the pathogenesis of arterial stiffening in CKD. We aimed to evaluate the relationship between arterial stiffness and immunosenescent T cell (CD8+CD57+ or CD8+CD28- T cell) fraction in patients with CKD