A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities

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dc.contributor.authorKochi, Yko
dc.contributor.authorYamada, Rko
dc.contributor.authorSuzuki, Ako
dc.contributor.authorHarley, JBko
dc.contributor.authorShirasawa, Sko
dc.contributor.authorSawada, Tko
dc.contributor.authorBae, SCko
dc.contributor.authorTokuhiro, Sko
dc.contributor.authorChang, XTko
dc.contributor.authorSekine, Ako
dc.contributor.authorTakahashi, Ako
dc.contributor.authorTsunoda, Tko
dc.contributor.authorOhnishi, Yko
dc.contributor.authorKaufman, KMko
dc.contributor.authorKang, CSPko
dc.contributor.authorKANG, Changwonko
dc.contributor.authorOtsubo, Sko
dc.contributor.authorYumura, Wko
dc.contributor.authorMimori, Ako
dc.contributor.authorKoike, Tko
dc.contributor.authorNakamura, Yko
dc.contributor.authorSasazuki, Tko
dc.contributor.authorYamamoto, Kko
dc.date.accessioned2007-11-29T09:19:20Z-
dc.date.available2007-11-29T09:19:20Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2005-02-
dc.identifier.citationNATURE GENETICS, v.37, no.5, pp.478 - 485-
dc.identifier.issn1061-4036-
dc.identifier.urihttp://hdl.handle.net/10203/2240-
dc.descriptionhttp://www.nature.com/ng/journal/v37/n5/full/ng1540.htmlen
dc.description.abstractRheumatoid arthritis is a common autoimmune disease with a complex genetic etiology. Here we identify a SNP in the promoter region of FCRL3, a member of the Fc receptor-like family, that is associated with susceptibility to rheumatoid arthritis ( odds ratio = 2.15, P = 0.00000085). This polymorphism alters the binding affinity of nuclear factor-κ B and regulates FCRL3 expression. We observed high FCRL3 expression on B cells and augmented autoantibody production in individuals with the disease-susceptible genotype. We also found associations between the SNP and susceptibility to autoimmune thyroid disease and systemic lupus erythematosus. FCRL3 may therefore have a pivotal role in autoimmunity.-
dc.description.sponsorshipthe Korean Molecular and Cellular BioDiscovery Research Programen
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherNATURE PUBLISHING GROUP-
dc.subjectSYSTEMIC-LUPUS-ERYTHEMATOSUS-
dc.subjectGENETIC SUSCEPTIBILITY-
dc.subjectREVISED CRITERIA-
dc.subjectCHROMOSOME 1Q21-
dc.subjectB-CELLS-
dc.subjectFAMILY-
dc.subjectPOLYMORPHISMS-
dc.subjectIDENTIFICATION-
dc.subjectPOPULATION-
dc.subjectPSORIASIS-
dc.titleA functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities-
dc.typeArticle-
dc.identifier.wosid000228862300016-
dc.identifier.scopusid2-s2.0-20944434679-
dc.type.rimsART-
dc.citation.volume37-
dc.citation.issue5-
dc.citation.beginningpage478-
dc.citation.endingpage485-
dc.citation.publicationnameNATURE GENETICS-
dc.identifier.doi10.1038/ng1540-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorKANG, Changwon-
dc.contributor.nonIdAuthorKochi, Y-
dc.contributor.nonIdAuthorYamada, R-
dc.contributor.nonIdAuthorSuzuki, A-
dc.contributor.nonIdAuthorHarley, JB-
dc.contributor.nonIdAuthorShirasawa, S-
dc.contributor.nonIdAuthorSawada, T-
dc.contributor.nonIdAuthorBae, SC-
dc.contributor.nonIdAuthorTokuhiro, S-
dc.contributor.nonIdAuthorChang, XT-
dc.contributor.nonIdAuthorSekine, A-
dc.contributor.nonIdAuthorTakahashi, A-
dc.contributor.nonIdAuthorTsunoda, T-
dc.contributor.nonIdAuthorOhnishi, Y-
dc.contributor.nonIdAuthorKaufman, KM-
dc.contributor.nonIdAuthorKang, CSP-
dc.contributor.nonIdAuthorOtsubo, S-
dc.contributor.nonIdAuthorYumura, W-
dc.contributor.nonIdAuthorMimori, A-
dc.contributor.nonIdAuthorKoike, T-
dc.contributor.nonIdAuthorNakamura, Y-
dc.contributor.nonIdAuthorSasazuki, T-
dc.contributor.nonIdAuthorYamamoto, K-
dc.type.journalArticleArticle-
dc.subject.keywordPlusSYSTEMIC-LUPUS-ERYTHEMATOSUS-
dc.subject.keywordPlusGENETIC SUSCEPTIBILITY-
dc.subject.keywordPlusREVISED CRITERIA-
dc.subject.keywordPlusCHROMOSOME 1Q21-
dc.subject.keywordPlusB-CELLS-
dc.subject.keywordPlusFAMILY-
dc.subject.keywordPlusPOLYMORPHISMS-
dc.subject.keywordPlusIDENTIFICATION-
dc.subject.keywordPlusPOPULATION-
dc.subject.keywordPlusPSORIASIS-
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