DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kochi, Y | ko |
dc.contributor.author | Yamada, R | ko |
dc.contributor.author | Suzuki, A | ko |
dc.contributor.author | Harley, JB | ko |
dc.contributor.author | Shirasawa, S | ko |
dc.contributor.author | Sawada, T | ko |
dc.contributor.author | Bae, SC | ko |
dc.contributor.author | Tokuhiro, S | ko |
dc.contributor.author | Chang, XT | ko |
dc.contributor.author | Sekine, A | ko |
dc.contributor.author | Takahashi, A | ko |
dc.contributor.author | Tsunoda, T | ko |
dc.contributor.author | Ohnishi, Y | ko |
dc.contributor.author | Kaufman, KM | ko |
dc.contributor.author | Kang, CSP | ko |
dc.contributor.author | KANG, Changwon | ko |
dc.contributor.author | Otsubo, S | ko |
dc.contributor.author | Yumura, W | ko |
dc.contributor.author | Mimori, A | ko |
dc.contributor.author | Koike, T | ko |
dc.contributor.author | Nakamura, Y | ko |
dc.contributor.author | Sasazuki, T | ko |
dc.contributor.author | Yamamoto, K | ko |
dc.date.accessioned | 2007-11-29T09:19:20Z | - |
dc.date.available | 2007-11-29T09:19:20Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2005-02 | - |
dc.identifier.citation | NATURE GENETICS, v.37, no.5, pp.478 - 485 | - |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.uri | http://hdl.handle.net/10203/2240 | - |
dc.description | http://www.nature.com/ng/journal/v37/n5/full/ng1540.html | en |
dc.description.abstract | Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology. Here we identify a SNP in the promoter region of FCRL3, a member of the Fc receptor-like family, that is associated with susceptibility to rheumatoid arthritis ( odds ratio = 2.15, P = 0.00000085). This polymorphism alters the binding affinity of nuclear factor-κ B and regulates FCRL3 expression. We observed high FCRL3 expression on B cells and augmented autoantibody production in individuals with the disease-susceptible genotype. We also found associations between the SNP and susceptibility to autoimmune thyroid disease and systemic lupus erythematosus. FCRL3 may therefore have a pivotal role in autoimmunity. | - |
dc.description.sponsorship | the Korean Molecular and Cellular BioDiscovery Research Program | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | GENETIC SUSCEPTIBILITY | - |
dc.subject | REVISED CRITERIA | - |
dc.subject | CHROMOSOME 1Q21 | - |
dc.subject | B-CELLS | - |
dc.subject | FAMILY | - |
dc.subject | POLYMORPHISMS | - |
dc.subject | IDENTIFICATION | - |
dc.subject | POPULATION | - |
dc.subject | PSORIASIS | - |
dc.title | A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities | - |
dc.type | Article | - |
dc.identifier.wosid | 000228862300016 | - |
dc.identifier.scopusid | 2-s2.0-20944434679 | - |
dc.type.rims | ART | - |
dc.citation.volume | 37 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 478 | - |
dc.citation.endingpage | 485 | - |
dc.citation.publicationname | NATURE GENETICS | - |
dc.identifier.doi | 10.1038/ng1540 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | KANG, Changwon | - |
dc.contributor.nonIdAuthor | Kochi, Y | - |
dc.contributor.nonIdAuthor | Yamada, R | - |
dc.contributor.nonIdAuthor | Suzuki, A | - |
dc.contributor.nonIdAuthor | Harley, JB | - |
dc.contributor.nonIdAuthor | Shirasawa, S | - |
dc.contributor.nonIdAuthor | Sawada, T | - |
dc.contributor.nonIdAuthor | Bae, SC | - |
dc.contributor.nonIdAuthor | Tokuhiro, S | - |
dc.contributor.nonIdAuthor | Chang, XT | - |
dc.contributor.nonIdAuthor | Sekine, A | - |
dc.contributor.nonIdAuthor | Takahashi, A | - |
dc.contributor.nonIdAuthor | Tsunoda, T | - |
dc.contributor.nonIdAuthor | Ohnishi, Y | - |
dc.contributor.nonIdAuthor | Kaufman, KM | - |
dc.contributor.nonIdAuthor | Kang, CSP | - |
dc.contributor.nonIdAuthor | Otsubo, S | - |
dc.contributor.nonIdAuthor | Yumura, W | - |
dc.contributor.nonIdAuthor | Mimori, A | - |
dc.contributor.nonIdAuthor | Koike, T | - |
dc.contributor.nonIdAuthor | Nakamura, Y | - |
dc.contributor.nonIdAuthor | Sasazuki, T | - |
dc.contributor.nonIdAuthor | Yamamoto, K | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | GENETIC SUSCEPTIBILITY | - |
dc.subject.keywordPlus | REVISED CRITERIA | - |
dc.subject.keywordPlus | CHROMOSOME 1Q21 | - |
dc.subject.keywordPlus | B-CELLS | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | POLYMORPHISMS | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | PSORIASIS | - |
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