A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities

Cited 282 time in webofscience Cited 0 time in scopus
  • Hit : 1112
  • Download : 552
Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology. Here we identify a SNP in the promoter region of FCRL3, a member of the Fc receptor-like family, that is associated with susceptibility to rheumatoid arthritis ( odds ratio = 2.15, P = 0.00000085). This polymorphism alters the binding affinity of nuclear factor-κ B and regulates FCRL3 expression. We observed high FCRL3 expression on B cells and augmented autoantibody production in individuals with the disease-susceptible genotype. We also found associations between the SNP and susceptibility to autoimmune thyroid disease and systemic lupus erythematosus. FCRL3 may therefore have a pivotal role in autoimmunity.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2005-02
Language
English
Article Type
Article
Description

http://www.nature.com/ng/journal/v37/n5/full/ng1540.html

Keywords

SYSTEMIC-LUPUS-ERYTHEMATOSUS; GENETIC SUSCEPTIBILITY; REVISED CRITERIA; CHROMOSOME 1Q21; B-CELLS; FAMILY; POLYMORPHISMS; IDENTIFICATION; POPULATION; PSORIASIS

Citation

NATURE GENETICS, v.37, no.5, pp.478 - 485

ISSN
1061-4036
DOI
10.1038/ng1540
URI
http://hdl.handle.net/10203/2240
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 282 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0