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College of Life Science and Bioengineering(생명과학기술대학)Dept. of Biological Sciences(생명과학과)BS-Journal Papers(저널논문)

Excitation/Inhibition Imbalance in Animal Models of Autism Spectrum Disorders

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dc.contributor.authorLee, Euneeko
dc.contributor.authorLee, Jiseokko
dc.contributor.authorKim, Eunjoonko
dc.date.accessioned2017-06-05T02:04:51Z-
dc.date.available2017-06-05T02:04:51Z-
dc.date.created2017-05-22-
dc.date.created2017-05-22-
dc.date.issued2017-05-
dc.identifier.citationBIOLOGICAL PSYCHIATRY, v.81, no.10, pp.838 - 847-
dc.identifier.issn0006-3223-
dc.identifier.urihttp://hdl.handle.net/10203/223835-
dc.description.abstractImbalances between excitation and inhibition in synaptic transmission and neural circuits have been implicated in autism spectrum disorders. Excitation and inhibition imbalances are frequently observed in animal models of autism spectrum disorders, and their correction normalizes key autistic-like phenotypes in these animals. These results suggest that excitation and inhibition imbalances may contribute to the development and maintenance of autism spectrum disorders and represent an important therapeutic target.-
dc.languageEnglish-
dc.publisherELSEVIER SCIENCE INC-
dc.subjectFRAGILE-X-SYNDROME-
dc.subjectLONG-TERM POTENTIATION-
dc.subjectCYCLOSERINE IMPROVES SOCIABILITY-
dc.subjectTUBEROUS SCLEROSIS COMPLEX-
dc.subjectMEDIAL PREFRONTAL CORTEX-
dc.subjectANGELMAN SYNDROME MODEL-
dc.subjectMGLUR5 ANTAGONIST MPEP-
dc.subjectBTBR MOUSE MODEL-
dc.subjectRETT-SYNDROME-
dc.subjectSYNAPTIC-TRANSMISSION-
dc.titleExcitation/Inhibition Imbalance in Animal Models of Autism Spectrum Disorders-
dc.typeArticle-
dc.identifier.wosid000400335100005-
dc.identifier.scopusid2-s2.0-84979538965-
dc.type.rimsART-
dc.citation.volume81-
dc.citation.issue10-
dc.citation.beginningpage838-
dc.citation.endingpage847-
dc.citation.publicationnameBIOLOGICAL PSYCHIATRY-
dc.identifier.doi10.1016/j.biopsych.2016.05.011-
dc.contributor.localauthorKim, Eunjoon-
dc.description.isOpenAccessY-
dc.type.journalArticleReview-
dc.subject.keywordAuthorAutism spectrum disorders-
dc.subject.keywordAuthorCircuit-
dc.subject.keywordAuthorExcitation/inhibition balance-
dc.subject.keywordAuthorMouse models-
dc.subject.keywordAuthorPsychiatric disorders-
dc.subject.keywordAuthorSynapse-
dc.subject.keywordPlusFRAGILE-X-SYNDROME-
dc.subject.keywordPlusLONG-TERM POTENTIATION-
dc.subject.keywordPlusCYCLOSERINE IMPROVES SOCIABILITY-
dc.subject.keywordPlusTUBEROUS SCLEROSIS COMPLEX-
dc.subject.keywordPlusMEDIAL PREFRONTAL CORTEX-
dc.subject.keywordPlusANGELMAN SYNDROME MODEL-
dc.subject.keywordPlusMGLUR5 ANTAGONIST MPEP-
dc.subject.keywordPlusBTBR MOUSE MODEL-
dc.subject.keywordPlusRETT-SYNDROME-
dc.subject.keywordPlusSYNAPTIC-TRANSMISSION-
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