DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, Kiwon | ko |
dc.contributor.author | Kim, Kwoneel | ko |
dc.contributor.author | Cho, Ara | ko |
dc.contributor.author | Lee, Insuk | ko |
dc.contributor.author | Choi, Jung Kyoon | ko |
dc.date.accessioned | 2017-05-08T08:46:33Z | - |
dc.date.available | 2017-05-08T08:46:33Z | - |
dc.date.created | 2017-04-18 | - |
dc.date.created | 2017-04-18 | - |
dc.date.issued | 2017-03 | - |
dc.identifier.citation | PLOS COMPUTATIONAL BIOLOGY, v.13, no.3 | - |
dc.identifier.issn | 1553-734X | - |
dc.identifier.uri | http://hdl.handle.net/10203/223455 | - |
dc.description.abstract | Cancer driving genes have been identified as recurrently affected by variants that alter protein-coding sequences. However, a majority of cancer variants arise in noncoding regions, and some of them are thought to play a critical role through transcriptional perturbation. Here we identified putative transcriptional driver genes based on combinatorial variant recurrence in cis-regulatory regions. The identified genes showed high connectivity in the cancer type-specific transcription regulatory network, with high outdegree and many downstream genes, highlighting their causative role during tumorigenesis. In the protein interactome, the identified transcriptional drivers were not as highly connected as coding driver genes but appeared to form a network module centered on the coding drivers. The coding and regulatory variants associated via these interactions between the coding and transcriptional drivers showed exclusive and complementary occurrence patterns across tumor samples. Transcriptional cancer drivers may act through an extensive perturbation of the regulatory network and by altering protein network modules through interactions with coding driver genes. | - |
dc.language | English | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | TERT PROMOTER MUTATIONS | - |
dc.subject | HUMAN CELL-TYPES | - |
dc.subject | CHROMATIN INTERACTOME | - |
dc.subject | DISEASE | - |
dc.subject | GENES | - |
dc.subject | PATHWAYS | - |
dc.subject | DNA | - |
dc.subject | MELANOMA | - |
dc.subject | GENOMES | - |
dc.subject | BINDING | - |
dc.title | Network perturbation by recurrent regulatory variants in cancer | - |
dc.type | Article | - |
dc.identifier.wosid | 000398031900019 | - |
dc.identifier.scopusid | 2-s2.0-85016822645 | - |
dc.type.rims | ART | - |
dc.citation.volume | 13 | - |
dc.citation.issue | 3 | - |
dc.citation.publicationname | PLOS COMPUTATIONAL BIOLOGY | - |
dc.identifier.doi | 10.1371/journal.pcbi.1005449 | - |
dc.contributor.localauthor | Choi, Jung Kyoon | - |
dc.contributor.nonIdAuthor | Cho, Ara | - |
dc.contributor.nonIdAuthor | Lee, Insuk | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | TERT PROMOTER MUTATIONS | - |
dc.subject.keywordPlus | HUMAN CELL-TYPES | - |
dc.subject.keywordPlus | CHROMATIN INTERACTOME | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | MELANOMA | - |
dc.subject.keywordPlus | GENOMES | - |
dc.subject.keywordPlus | BINDING | - |
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