DC Field | Value | Language |
---|---|---|
dc.contributor.author | Levantino, Matteo | ko |
dc.contributor.author | Schiro, Giorgio | ko |
dc.contributor.author | Lemke, Henrik Till | ko |
dc.contributor.author | Cottone, Grazia | ko |
dc.contributor.author | Glownia, James Michael | ko |
dc.contributor.author | Zhu, Diling | ko |
dc.contributor.author | Chollet, Mathieu | ko |
dc.contributor.author | Ihee, Hyot-Cherl | ko |
dc.contributor.author | Cupane, Antonio | ko |
dc.contributor.author | Cammarata, Marco | ko |
dc.date.accessioned | 2017-04-17T07:14:14Z | - |
dc.date.available | 2017-04-17T07:14:14Z | - |
dc.date.created | 2015-06-01 | - |
dc.date.created | 2015-06-01 | - |
dc.date.created | 2015-06-01 | - |
dc.date.created | 2015-06-01 | - |
dc.date.issued | 2015-04 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v.6 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10203/223208 | - |
dc.description.abstract | Light absorption can trigger biologically relevant protein conformational changes. The lightinduced structural rearrangement at the level of a photoexcited chromophore is known to occur in the femtosecond timescale and is expected to propagate through the protein as a quake-like intramolecular motion. Here we report direct experimental evidence of such 'proteinquake' observed in myoglobin through femtosecond X-ray solution scattering measurements performed at the Linac Coherent Light Source X-ray free-electron laser. An ultrafast increase of myoglobin radius of gyration occurs within 1 picosecond and is followed by a delayed protein expansion. As the system approaches equilibrium it undergoes damped oscillations with a similar to 3.6-picosecond time period. Our results unambiguously show how initially localized chemical changes can propagate at the level of the global protein conformation in the picosecond timescale. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Ultrafast myoglobin structural dynamics observed with an X-ray free-electron laser | - |
dc.type | Article | - |
dc.identifier.wosid | 000353702500012 | - |
dc.identifier.scopusid | 2-s2.0-84926341826 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.publicationname | NATURE COMMUNICATIONS | - |
dc.identifier.doi | 10.1038/ncomms7772 | - |
dc.contributor.localauthor | Ihee, Hyot-Cherl | - |
dc.contributor.nonIdAuthor | Levantino, Matteo | - |
dc.contributor.nonIdAuthor | Schiro, Giorgio | - |
dc.contributor.nonIdAuthor | Lemke, Henrik Till | - |
dc.contributor.nonIdAuthor | Cottone, Grazia | - |
dc.contributor.nonIdAuthor | Glownia, James Michael | - |
dc.contributor.nonIdAuthor | Zhu, Diling | - |
dc.contributor.nonIdAuthor | Chollet, Mathieu | - |
dc.contributor.nonIdAuthor | Cupane, Antonio | - |
dc.contributor.nonIdAuthor | Cammarata, Marco | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | NORMAL-MODE ANALYSIS | - |
dc.subject.keywordPlus | CARBONMONOXY-MYOGLOBIN | - |
dc.subject.keywordPlus | HEME-PROTEINS | - |
dc.subject.keywordPlus | CONFORMATIONAL-CHANGE | - |
dc.subject.keywordPlus | MOLECULAR-DYNAMICS | - |
dc.subject.keywordPlus | LIGAND-BINDING | - |
dc.subject.keywordPlus | RELAXATION | - |
dc.subject.keywordPlus | SCATTERING | - |
dc.subject.keywordPlus | RAMAN | - |
dc.subject.keywordPlus | PHOTODISSOCIATION | - |
dc.subject.keywordPlus | NORMAL-MODE ANALYSIS | - |
dc.subject.keywordPlus | CARBONMONOXY-MYOGLOBIN | - |
dc.subject.keywordPlus | HEME-PROTEINS | - |
dc.subject.keywordPlus | CONFORMATIONAL-CHANGE | - |
dc.subject.keywordPlus | MOLECULAR-DYNAMICS | - |
dc.subject.keywordPlus | LIGAND-BINDING | - |
dc.subject.keywordPlus | RELAXATION | - |
dc.subject.keywordPlus | SCATTERING | - |
dc.subject.keywordPlus | RAMAN | - |
dc.subject.keywordPlus | PHOTODISSOCIATION | - |
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