Butanol 생합성 Clostridium 속 미생물 대사공학용 게놈 편집 도구 개발Development of Genome Engineering Tools for Metabolic Engineering of Butanol-producing Clostridium Species

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Global warming caused from the heavy consumption of fossil fuel is one of the biggest problems to be solved. Biofuel has been gained more attention as an alternative to reduce the consumption of fossil fuel. Recently, butanol produced from the genus Clostridium has been considered as one of the promising alternatives for gasoline, fossil based fuel. Nevertheless, the lack of the genome-engineering tools for the genus Clostridium is the major hurdle for the economic productionof butanol. More recently, genome engineering toolshave been developed for metabolic engineering of butanolproducingClostridium species, which includes genome scalenetwork model and genome editing tools on the basis of mobilegroup II introns and CRISPR/Cas system. In this study, thegenome engineering tools for butanol-producing Clostridiumspecies have been reviewed with a brief future perspective.
Publisher
한국생물공학회
Issue Date
2016-12
Language
Korean
Keywords

Clostridium; Genome engineering; Butanol; Mobile intron; CRISPR

Citation

KSBB Journal, v.31, no.4, pp.193 - 199

ISSN
1225-7117
URI
http://hdl.handle.net/10203/223132
Appears in Collection
CBE-Journal Papers(저널논문)
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