Regulation of BC200 RNA-mediated translation inhibition by hnRNP E1 and E2

Cited 18 time in webofscience Cited 0 time in scopus
  • Hit : 534
  • Download : 0
The long noncoding RNA BC200 ( brain cytoplasmic RNA, 200 nucleotides) acts as a translational modulator of local protein synthesis at dendrites. BC200 RNA has been shown to inhibit translation in vitro, but it remains unknown how this translation inhibition might be controlled in a cell. Here, we performed yeast three-hybrid screening and identified hnRNP E1 and hnRNP E2 as BC200 RNA-interacting proteins. We found that: these hnRNA proteins could restore BC200 RNA-inhibited translation; BC200 RNA interacts with hnRNP E1 and E2 mainly through its unique 30 C-rich domain; and the RNA binding specificities and modes of the two proteins differed somewhat. Our results offer new insights into the regulation of BC200 RNA-mediated translation inhibition.
Publisher
WILEY-BLACKWELL
Issue Date
2017-01
Language
English
Article Type
Article
Keywords

LONG NONCODING RNA; DENDRITIC BC1 RNA; MESSENGER-RNA; BINDING-PROTEINS; ERYTHROID-DIFFERENTIATION; POLY(C)-BINDING PROTEINS; POLY(A)-BINDING PROTEIN; GENE-EXPRESSION; POLIOVIRUS RNA; BREAST-CANCER

Citation

FEBS LETTERS, v.591, no.2, pp.393 - 405

ISSN
0014-5793
DOI
10.1002/1873-3468.12544
URI
http://hdl.handle.net/10203/222768
Appears in Collection
CH-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 18 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0