Effective Retinal Penetration of Lipophilic and Lipid-Conjugated Hydrophilic Agents Delivered by Engineered Liposomes

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dc.contributor.authorLee, Junsungko
dc.contributor.authorGoh, Unbyeolko
dc.contributor.authorLee, Hyoung-Jinko
dc.contributor.authorKim, Jiyoungko
dc.contributor.authorJeong, Moonkyoungko
dc.contributor.authorPark, Ji-Hoko
dc.date.accessioned2017-03-30T09:19:53Z-
dc.date.available2017-03-30T09:19:53Z-
dc.date.created2017-01-04-
dc.date.created2017-01-04-
dc.date.issued2017-02-
dc.identifier.citationMOLECULAR PHARMACEUTICS, v.14, no.2, pp.423 - 430-
dc.identifier.issn1543-8384-
dc.identifier.urihttp://hdl.handle.net/10203/222741-
dc.description.abstractEfficient delivery of drugs to the retina is critical but difficult to achieve with current methods. There have been a number of attempts to use intravitreal injection of liposomes, artificial vesicles composed of a phospholipid bilayer, to overcome the limitations of conventional intravitreal injection (short retention time, toxicity, poor penetration, etc.). Here, we report an optimal liposomal formulation that can diffuse through the vitreous humor, deliver the incorporated agents to all retinal layers effectively, and maintain them for a relatively long time. We first delivered lipophilic compounds and phospholipid-conjugated hydrophilic agents to the inner limiting membrane using engineered liposomes. Subsequently, the agents penetrated the retina deeply, presumably via extracellular vesicles, nanoscale vesicles secreted from retinal-associated cells. These results suggest that this engineered liposomal formulation can leverage the biological transport system for effective retinal penetration of lipophilic and lipid-conjugated agents.-
dc.languageEnglish-
dc.publisherAMER CHEMICAL SOC-
dc.subjectOCULAR GENE-THERAPY-
dc.subjectINTRAVITREAL INJECTION-
dc.subjectDRUG-DELIVERY-
dc.subjectCHOROIDAL NEOVASCULARIZATION-
dc.subjectNANOPARTICLE DIFFUSION-
dc.subjectPOSTERIOR SEGMENT-
dc.subjectT-CELLS-
dc.subjectOPHTHALMOLOGY-
dc.subjectEXOSOMES-
dc.subjectSYSTEMS-
dc.titleEffective Retinal Penetration of Lipophilic and Lipid-Conjugated Hydrophilic Agents Delivered by Engineered Liposomes-
dc.typeArticle-
dc.identifier.wosid000393630100009-
dc.identifier.scopusid2-s2.0-85011665201-
dc.type.rimsART-
dc.citation.volume14-
dc.citation.issue2-
dc.citation.beginningpage423-
dc.citation.endingpage430-
dc.citation.publicationnameMOLECULAR PHARMACEUTICS-
dc.identifier.doi10.1021/acs.molpharmaceut.6b00864-
dc.contributor.localauthorPark, Ji-Ho-
dc.contributor.nonIdAuthorGoh, Unbyeol-
dc.contributor.nonIdAuthorLee, Hyoung-Jin-
dc.contributor.nonIdAuthorKim, Jiyoung-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthordrug delivery-
dc.subject.keywordAuthorextracellular vesicle-
dc.subject.keywordAuthorliposome-
dc.subject.keywordAuthorphospholipid-
dc.subject.keywordAuthorretina-
dc.subject.keywordPlusOCULAR GENE-THERAPY-
dc.subject.keywordPlusINTRAVITREAL INJECTION-
dc.subject.keywordPlusDRUG-DELIVERY-
dc.subject.keywordPlusCHOROIDAL NEOVASCULARIZATION-
dc.subject.keywordPlusNANOPARTICLE DIFFUSION-
dc.subject.keywordPlusPOSTERIOR SEGMENT-
dc.subject.keywordPlusT-CELLS-
dc.subject.keywordPlusOPHTHALMOLOGY-
dc.subject.keywordPlusEXOSOMES-
dc.subject.keywordPlusSYSTEMS-
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