DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, You Hyang | ko |
dc.contributor.author | Kim, Jae-Hyun | ko |
dc.contributor.author | Jeong, Hye-Won | ko |
dc.contributor.author | Choi, Ilsong | ko |
dc.contributor.author | Jeong, Daun | ko |
dc.contributor.author | Kim, Kwansoo | ko |
dc.contributor.author | Lee, Seung-Hee | ko |
dc.date.accessioned | 2017-03-30T09:19:48Z | - |
dc.date.available | 2017-03-30T09:19:48Z | - |
dc.date.created | 2017-01-04 | - |
dc.date.created | 2017-01-04 | - |
dc.date.issued | 2017-02 | - |
dc.identifier.citation | NEURON, v.93, no.4, pp.940 - 940 | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | http://hdl.handle.net/10203/222740 | - |
dc.description.abstract | When conflicts occur during integration of visual and auditory information, one modality often dominates the other, but the underlying neural circuit mechanism remains unclear. Using auditory-visual discrimination tasks for head-fixed mice, we found that audition dominates vision in a process mediated by interaction between inputs from the primary visual (VC) and auditory (AC) cortices in the posterior parietal cortex (PTLp). Co-activation of the VC and AC suppresses VC-induced PTLp responses, leaving AC-induced responses. Furthermore, parvalbumin-positive (PV+) interneurons in the PTLp mainly receive AC inputs, and muscimol inactivation of the PTLp or optogenetic inhibition of its PV+ neurons abolishes auditory dominance in the resolution of cross-modal sensory conflicts without affecting either sensory perception. Conversely, optogenetic activation of PV+ neurons in the PTLp enhances the auditory dominance. Thus, our results demonstrate that AC input-specific feedforward inhibition of VC inputs in the PTLp is responsible for the auditory dominance during cross-modal integration. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.subject | MULTISENSORY INTEGRATION | - |
dc.subject | SUPERIOR COLLICULUS | - |
dc.subject | CORTICAL MICROSTIMULATION | - |
dc.subject | SINGLE NEURON | - |
dc.subject | CORTEX | - |
dc.subject | INFORMATION | - |
dc.subject | BEHAVIOR | - |
dc.subject | HUMANS | - |
dc.subject | AREAS | - |
dc.subject | CONVERGENCE | - |
dc.title | A Neural Circuit for Auditory Dominance over Visual Perception | - |
dc.type | Article | - |
dc.identifier.wosid | 000396429100021 | - |
dc.identifier.scopusid | 2-s2.0-85011308986 | - |
dc.type.rims | ART | - |
dc.citation.volume | 93 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 940 | - |
dc.citation.endingpage | 940 | - |
dc.citation.publicationname | NEURON | - |
dc.identifier.doi | 10.1016/j.neuron.2017.01.006 | - |
dc.contributor.localauthor | Lee, Seung-Hee | - |
dc.contributor.nonIdAuthor | Jeong, Hye-Won | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | MULTISENSORY INTEGRATION | - |
dc.subject.keywordPlus | SUPERIOR COLLICULUS | - |
dc.subject.keywordPlus | CORTICAL MICROSTIMULATION | - |
dc.subject.keywordPlus | SINGLE NEURON | - |
dc.subject.keywordPlus | CORTEX | - |
dc.subject.keywordPlus | INFORMATION | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | HUMANS | - |
dc.subject.keywordPlus | AREAS | - |
dc.subject.keywordPlus | CONVERGENCE | - |
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