DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Songmi | ko |
dc.contributor.author | Yang, Aerin | ko |
dc.contributor.author | Lee, Soonjang | ko |
dc.contributor.author | Lee, Han-Woong | ko |
dc.contributor.author | Park, Chan Bae | ko |
dc.contributor.author | Park, Hee-Sung | ko |
dc.date.accessioned | 2017-03-30T09:19:10Z | - |
dc.date.available | 2017-03-30T09:19:10Z | - |
dc.date.created | 2017-03-20 | - |
dc.date.created | 2017-03-20 | - |
dc.date.issued | 2017-02 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v.8 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10203/222730 | - |
dc.description.abstract | Here we report the expansion of the genetic code of Mus musculus with various unnatural amino acids including Ne-acetyl-lysine. Stable integration of transgenes encoding an engineered Ne-acetyl-lysyl-tRNA synthetase (AcKRS)/tRNAPyl pair into the mouse genome enables site-specific incorporation of unnatural amino acids into a target protein in response to the amber codon. We demonstrate temporal and spatial control of protein acetylation in various organs of the transgenic mouse using a recombinant green fluorescent protein (GFPuv) as a model protein. This strategy will provide a powerful tool for systematic in vivo study of cellular proteins in the most commonly used mammalian model organism for human physiology and disease. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | MESSENGER-RNA DECAY | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | CHEMISTRY | - |
dc.subject | PROTEINS | - |
dc.subject | BIOLOGY | - |
dc.subject | CANCER | - |
dc.subject | MTDNA | - |
dc.title | Expanding the genetic code of Mus musculus | - |
dc.type | Article | - |
dc.identifier.wosid | 000394499700001 | - |
dc.identifier.scopusid | 2-s2.0-85013408454 | - |
dc.type.rims | ART | - |
dc.citation.volume | 8 | - |
dc.citation.publicationname | NATURE COMMUNICATIONS | - |
dc.identifier.doi | 10.1038/ncomms14568 | - |
dc.contributor.localauthor | Park, Hee-Sung | - |
dc.contributor.nonIdAuthor | Han, Songmi | - |
dc.contributor.nonIdAuthor | Lee, Soonjang | - |
dc.contributor.nonIdAuthor | Lee, Han-Woong | - |
dc.contributor.nonIdAuthor | Park, Chan Bae | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | MESSENGER-RNA DECAY | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | CHEMISTRY | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | BIOLOGY | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | MTDNA | - |
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