Genetically engineered and self-assembled oncolytic protein nanoparticles for targeted cancer therapy

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dc.contributor.authorLee, Joong-jaeko
dc.contributor.authorKang, Jung Aeko
dc.contributor.authorRyu, Yiseulko
dc.contributor.authorHan, Sang-Sooko
dc.contributor.authorNam, You Reeko
dc.contributor.authorRho, Jong Kookko
dc.contributor.authorChoi, Dae Seongko
dc.contributor.authorKang, Sun-Woongko
dc.contributor.authorLee, Dong-Eunko
dc.contributor.authorKim, Hak-Sungko
dc.date.accessioned2017-03-30T09:17:37Z-
dc.date.available2017-03-30T09:17:37Z-
dc.date.created2017-03-29-
dc.date.created2017-03-29-
dc.date.issued2017-03-
dc.identifier.citationBIOMATERIALS, v.120, pp.22 - 31-
dc.identifier.issn0142-9612-
dc.identifier.urihttp://hdl.handle.net/10203/222697-
dc.description.abstractThe integration of a targeted delivery with a tumour-selective agent has been considered an ideal platform for achieving high therapeutic efficacy and negligible side effects in cancer therapy. Here, we present engineered protein nanoparticles comprising a tumour-selective oncolytic protein and a targeting moiety as a new format for the targeted cancer therapy. Apoptin from chicken anaemia virus (CAV) was used as a tumour-selective apoptotic protein. An EGFR-specific repebody, which is composed of LRR (Leucine-rich repeat) modules, was employed to play a dual role as a tumour-targeting moiety and a fusion partner for producing apoptin nanoparticles in E. coli, respectively. The repebody was genetically fused to apoptin, and the resulting fusion protein was shown to self-assemble into supramolecular repebody-apoptin nanoparticles with high homogeneity and stability as a soluble form when expressed in E. coli. The repebody-apoptin nanoparticles showed a remarkable anti-tumour activity with negligible side effects in xenograft mice through a cooperative action of the two protein components with distinct functional roles. The repebody-apoptin nanoparticles can be developed as a systemic injectable and tumour-selective therapeutic protein for targeted cancer treatment. (C) 2016 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherELSEVIER SCI LTD-
dc.subjectCHICKEN ANEMIA VIRUS-
dc.subjectTUMOR-CELLS-
dc.subjectIN-VITRO-
dc.subjectAPOPTIN-
dc.subjectDELIVERY-
dc.subjectAPOPTOSIS-
dc.subjectANTIBODY-
dc.subjectDRUGS-
dc.subjectEGFR-
dc.subjectVIVO-
dc.titleGenetically engineered and self-assembled oncolytic protein nanoparticles for targeted cancer therapy-
dc.typeArticle-
dc.identifier.wosid000394398900003-
dc.identifier.scopusid2-s2.0-85007236130-
dc.type.rimsART-
dc.citation.volume120-
dc.citation.beginningpage22-
dc.citation.endingpage31-
dc.citation.publicationnameBIOMATERIALS-
dc.identifier.doi10.1016/j.biomaterials.2016.12.014-
dc.contributor.localauthorKim, Hak-Sung-
dc.contributor.nonIdAuthorKang, Jung Ae-
dc.contributor.nonIdAuthorNam, You Ree-
dc.contributor.nonIdAuthorRho, Jong Kook-
dc.contributor.nonIdAuthorChoi, Dae Seong-
dc.contributor.nonIdAuthorKang, Sun-Woong-
dc.contributor.nonIdAuthorLee, Dong-Eun-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorTargeted delivery-
dc.subject.keywordAuthorCancer therapy-
dc.subject.keywordAuthorTumour selectivity-
dc.subject.keywordAuthorProtein nanoparticle-
dc.subject.keywordAuthorRepebody-
dc.subject.keywordAuthorSelf-assembly-
dc.subject.keywordPlusCHICKEN ANEMIA VIRUS-
dc.subject.keywordPlusTUMOR-CELLS-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusAPOPTIN-
dc.subject.keywordPlusDELIVERY-
dc.subject.keywordPlusAPOPTOSIS-
dc.subject.keywordPlusANTIBODY-
dc.subject.keywordPlusDRUGS-
dc.subject.keywordPlusEGFR-
dc.subject.keywordPlusVIVO-
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