Synthesis of new fluorescent probes for metal ions and reactive oxygen species selectively based on various fluorogenic molecules

Abstract

Herein, fluorescent probe is great tool for sensing analytes causing diseases. Based on main hypothesis of Alzheimer disease, three analytes are important

amyloid, metal ions, and reactive oxygen species. Especially metal ions and reactive oxygen species are more discussed on this book. As a first present work, we will introduce novel conjugation that involves benzothioimidazole substitution to a salicylaldehyde-functionalized BODIPY system. Important and unexpected chemosensing “turn on” response patterns were discovered for copper ion which were found to be solvent-dependent. These percentage changes of aqueous solvent ($CH_3CN : H_2O$) can be tuned to allow for clear and major fluorescence increases for both $Cu^{+}$ and $Cu^{2+}$ which can almost completely eliminate the $Hg^{2+}$ competitive signal. As a second present work, we will introduce dipyrrin ligand for chemosensing metal ions with reactive oxygen speices. Because of heavy atom effect by selenium, dipyrrin did not have fluorescence but it shows each different absorbance with $Fe^{2+}$, $Fe^{3+}$, $Cu^{2+}$, and $Zn^{2+}$ with only hypochlorite among other reactive oxygen species