Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

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Reduced mitochondria! electron transport chain activity promotes longevity and improves energy homeostasis via cell-autonomous and non-autonomous factors in multiple model systems. This mitohormetic effect is thought to involve the mitochondrial unfolded protein response (UPRmt), an adaptive stress-response pathway activated by mitochondria' proteotoxic stress. Using mice with skeletal muscle specific deficiency of Crifl (muscle-specific knockout [MKO]), an integral protein of the large mitoribosomal subunit (39S), we identified growth differentiation factor 15 (GDF15) as a UPRmt-associated cell non-autonomous myomitokine that regulates systemic energy homeostasis. MKO mice were protected against obesity and sensitized to insulin, an effect associated with elevated GDF15 secretion after UPRmt activation. In ob/ob mice, administration of recombinant GDF15 decreased body weight and improved insulin sensitivity, which was attributed to elevated oxidative metabolism and lipid mobilization in the liver, muscle, and adipose tissue. Thus, GDF15 is a potent mitohormetic signal that safeguards against the onset of obesity and insulin resistance.
Publisher
ROCKEFELLER UNIV PRESS
Issue Date
2017-01
Language
English
Article Type
Article
Citation

JOURNAL OF CELL BIOLOGY, v.216, no.1, pp.149 - 165

ISSN
0021-9525
DOI
10.1083/jcb.201607110
URI
http://hdl.handle.net/10203/220913
Appears in Collection
MSE-Journal Papers(저널논문)
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