Microdroplet-based Cell Culture Models and Their Application

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dc.contributor.authorJang, Minjeongko
dc.contributor.authorYang, Seungwonko
dc.contributor.authorKim, Pilnamko
dc.date.accessioned2017-01-23T02:54:04Z-
dc.date.available2017-01-23T02:54:04Z-
dc.date.created2016-11-11-
dc.date.created2016-11-11-
dc.date.issued2016-12-
dc.identifier.citationBIOCHIP JOURNAL, v.10, no.4, pp.310 - 317-
dc.identifier.issn1976-0280-
dc.identifier.urihttp://hdl.handle.net/10203/220177-
dc.description.abstractMicrofluidic systems offer precisely controlled experimental conditions for efficient study of mammalian cells, ranged from a single cell to matrix Based three-dimensional (3D) in vitro culture models. Droplet-based microfluidic system is a robust and highly reproducible device enabling encapsulation of a cell or cells within well-confined microenvironment. Recently, such droplet-based cell culture models have drawn much attention due to their unique properties such that conventional culture systems couldn't provide. The encapsulation of cells in specifically designed aqueous phase of a microfluidic system can provide profound understand of cell to cell and cell to extracellular matrix interactions, also can be used to regulate various cell behaviors. A droplet-based cell culture system allows better control over confinement for culturing, maintaining, and analyzing cells, such as high-throughput screening. In this review, we discuss recent researches on microdroplet-based 3D cell culture models, and advanced applications of microfluidic systems.-
dc.languageEnglish-
dc.publisherKOREAN BIOCHIP SOCIETY-KBCS-
dc.subjectDROPLET-BASED MICROFLUIDICS-
dc.subjectMESENCHYMAL STEM-CELLS-
dc.subjectMULTICELLULAR SPHEROIDS-
dc.subjectMICROENGINEERED HYDROGELS-
dc.subjectECM INTERACTIONS-
dc.subjectSINGLE-CELLS-
dc.subjectCANCER-CELLS-
dc.subjectDEVICE-
dc.subjectDIFFERENTIATION-
dc.subjectENCAPSULATION-
dc.titleMicrodroplet-based Cell Culture Models and Their Application-
dc.typeArticle-
dc.identifier.wosid000390288800007-
dc.identifier.scopusid2-s2.0-85008440380-
dc.type.rimsART-
dc.citation.volume10-
dc.citation.issue4-
dc.citation.beginningpage310-
dc.citation.endingpage317-
dc.citation.publicationnameBIOCHIP JOURNAL-
dc.identifier.doi10.1007/s13206-016-0407-1-
dc.identifier.kciidART002173860-
dc.contributor.localauthorKim, Pilnam-
dc.contributor.nonIdAuthorYang, Seungwon-
dc.description.isOpenAccessN-
dc.type.journalArticleReview-
dc.subject.keywordAuthorMicrodroplet-
dc.subject.keywordAuthor3D cell culture-
dc.subject.keywordAuthorHigh-throughput-
dc.subject.keywordAuthorSingle cell analysis-
dc.subject.keywordAuthorMulticellular spheroid-
dc.subject.keywordAuthorCell-laden ECM-
dc.subject.keywordPlusDROPLET-BASED MICROFLUIDICS-
dc.subject.keywordPlusMESENCHYMAL STEM-CELLS-
dc.subject.keywordPlusMULTICELLULAR SPHEROIDS-
dc.subject.keywordPlusMICROENGINEERED HYDROGELS-
dc.subject.keywordPlusECM INTERACTIONS-
dc.subject.keywordPlusSINGLE-CELLS-
dc.subject.keywordPlusCANCER-CELLS-
dc.subject.keywordPlusDEVICE-
dc.subject.keywordPlusDIFFERENTIATION-
dc.subject.keywordPlusENCAPSULATION-
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