DC Field | Value | Language |
---|---|---|
dc.contributor.author | Leung, Danny | ko |
dc.contributor.author | Jung, Inkyung | ko |
dc.contributor.author | Rajagopal, Nisha | ko |
dc.contributor.author | Schmitt, Anthony | ko |
dc.contributor.author | Selvaraj, Siddarth | ko |
dc.contributor.author | Lee, Ah Young | ko |
dc.contributor.author | Yen, Chia-An | ko |
dc.contributor.author | Lin, Shin | ko |
dc.contributor.author | Lin, Yiing | ko |
dc.contributor.author | Qiu, Yunjiang | ko |
dc.contributor.author | Xie, Wei | ko |
dc.contributor.author | Yue, Feng | ko |
dc.contributor.author | Hariharan, Manoj | ko |
dc.contributor.author | Ray, Pradipta | ko |
dc.contributor.author | Kuan, Samantha | ko |
dc.contributor.author | Edsall, Lee | ko |
dc.contributor.author | Yang, Hongbo | ko |
dc.contributor.author | Chi, Neil C. | ko |
dc.contributor.author | Zhang, Michael Q. | ko |
dc.contributor.author | Ecker, Joseph R. | ko |
dc.contributor.author | Ren, Bing | ko |
dc.date.accessioned | 2017-01-18T02:57:48Z | - |
dc.date.available | 2017-01-18T02:57:48Z | - |
dc.date.created | 2017-01-01 | - |
dc.date.created | 2017-01-01 | - |
dc.date.created | 2017-01-01 | - |
dc.date.created | 2017-01-01 | - |
dc.date.issued | 2015-02 | - |
dc.identifier.citation | NATURE, v.518, no.7539, pp.350 - 354 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | http://hdl.handle.net/10203/219691 | - |
dc.description.abstract | Allelic differences between the two homologous chromosomes can affect the propensity of inheritance in humans; however, the extent of such differences in the human genome has yet to be fully explored. Here we delineate allelic chromatin modifications and transcriptomes among a broad set of human tissues, enabled by a chromosome-spanning haplotype reconstruction strategy(1). The resulting large collection of haplotype-resolved epigenomic maps reveals extensive allelic biases in both chromatin state and transcription, which show considerable variation across tissues and between individuals, and allow us to investigate cis-regulatory relationships between genes and their control sequences. Analyses of histone modification maps also uncover intriguing characteristics of cis-regulatory elements and tissue-restricted activities of repetitive elements. The rich data sets described here will enhance our understanding of the mechanisms by which cis-regulatory elements control gene expression programs. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Integrative analysis of haplotype-resolved epigenomes across human tissues | - |
dc.type | Article | - |
dc.identifier.wosid | 000349547400032 | - |
dc.identifier.scopusid | 2-s2.0-84923333199 | - |
dc.type.rims | ART | - |
dc.citation.volume | 518 | - |
dc.citation.issue | 7539 | - |
dc.citation.beginningpage | 350 | - |
dc.citation.endingpage | 354 | - |
dc.citation.publicationname | NATURE | - |
dc.identifier.doi | 10.1038/nature14217 | - |
dc.contributor.localauthor | Jung, Inkyung | - |
dc.contributor.nonIdAuthor | Leung, Danny | - |
dc.contributor.nonIdAuthor | Rajagopal, Nisha | - |
dc.contributor.nonIdAuthor | Schmitt, Anthony | - |
dc.contributor.nonIdAuthor | Selvaraj, Siddarth | - |
dc.contributor.nonIdAuthor | Lee, Ah Young | - |
dc.contributor.nonIdAuthor | Yen, Chia-An | - |
dc.contributor.nonIdAuthor | Lin, Shin | - |
dc.contributor.nonIdAuthor | Lin, Yiing | - |
dc.contributor.nonIdAuthor | Qiu, Yunjiang | - |
dc.contributor.nonIdAuthor | Xie, Wei | - |
dc.contributor.nonIdAuthor | Yue, Feng | - |
dc.contributor.nonIdAuthor | Hariharan, Manoj | - |
dc.contributor.nonIdAuthor | Ray, Pradipta | - |
dc.contributor.nonIdAuthor | Kuan, Samantha | - |
dc.contributor.nonIdAuthor | Edsall, Lee | - |
dc.contributor.nonIdAuthor | Yang, Hongbo | - |
dc.contributor.nonIdAuthor | Chi, Neil C. | - |
dc.contributor.nonIdAuthor | Zhang, Michael Q. | - |
dc.contributor.nonIdAuthor | Ecker, Joseph R. | - |
dc.contributor.nonIdAuthor | Ren, Bing | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | EMBRYONIC STEM-CELLS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | ENHANCERS | - |
dc.subject.keywordPlus | GENOME | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | PROMOTERS | - |
dc.subject.keywordPlus | LANDSCAPE | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | ATLAS | - |
dc.subject.keywordPlus | STATE | - |
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