Integrative analysis of haplotype-resolved epigenomes across human tissues

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Allelic differences between the two homologous chromosomes can affect the propensity of inheritance in humans; however, the extent of such differences in the human genome has yet to be fully explored. Here we delineate allelic chromatin modifications and transcriptomes among a broad set of human tissues, enabled by a chromosome-spanning haplotype reconstruction strategy(1). The resulting large collection of haplotype-resolved epigenomic maps reveals extensive allelic biases in both chromatin state and transcription, which show considerable variation across tissues and between individuals, and allow us to investigate cis-regulatory relationships between genes and their control sequences. Analyses of histone modification maps also uncover intriguing characteristics of cis-regulatory elements and tissue-restricted activities of repetitive elements. The rich data sets described here will enhance our understanding of the mechanisms by which cis-regulatory elements control gene expression programs.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2015-02
Language
English
Article Type
Article
Citation

NATURE, v.518, no.7539, pp.350 - 354

ISSN
0028-0836
DOI
10.1038/nature14217
URI
http://hdl.handle.net/10203/219691
Appears in Collection
BS-Journal Papers(저널논문)
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