DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cha, Seho | ko |
dc.contributor.author | Choe, Joonho | ko |
dc.contributor.author | Seo, Taegun | ko |
dc.date.accessioned | 2016-12-14T02:22:43Z | - |
dc.date.available | 2016-12-14T02:22:43Z | - |
dc.date.created | 2016-12-06 | - |
dc.date.created | 2016-12-06 | - |
dc.date.issued | 2016-10 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.479, no.4, pp.697 - 702 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10203/214837 | - |
dc.description.abstract | Kaposi's sarcoma-associated herpesvirus (KSHV) is an etiological agent of Kaposi's sarcoma and primary effusion lymphoma. Like other herpesviruses, KSHV has two distinct life cycles: latent and lytic. Among KSHV latent genes, viral interferon regulatory factor 3 (vIRF3), which shares homology with cellular IRFs, is a multifunctional protein. To identify unknown functions of vIRF3, we performed luciferase-reporter assays in the presence of vIRF3. These analyses revealed that overexpression of vIRF3 inhibited T-cell factor (TCF)-dependent transcriptional activity. This TCF-dependent transcription was associated with the Wnt signaling pathway, which normally regulates embryonic development, but contributes to oncogenesis under dysregulated conditions. Using a mutagenesis analysis, we identified a CREB-binding protein-interaction motif (LXXLL) in vIRF3 as an important region for its inhibitory activity. Collectively, our findings provide insight into the dysregulation of host signaling pathways in KSHV-infected cells. (C) 2016 Elsevier Inc. All rights reserved | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | INTERFERON-REGULATORY FACTOR-3 | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | BETA-CATENIN | - |
dc.subject | LATENT | - |
dc.subject | LANA2 | - |
dc.subject | IDENTIFICATION | - |
dc.subject | ACTIVATION | - |
dc.subject | TARGET | - |
dc.subject | SIGNAL | - |
dc.subject | ALPHA | - |
dc.title | vIRF3 encoded by Kaposi's sarcoma-associated herpesvirus inhibits T-cell factor-dependent transcription via a CREB-binding protein interaction motif | - |
dc.type | Article | - |
dc.identifier.wosid | 000387200300015 | - |
dc.identifier.scopusid | 2-s2.0-84991449475 | - |
dc.type.rims | ART | - |
dc.citation.volume | 479 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 697 | - |
dc.citation.endingpage | 702 | - |
dc.citation.publicationname | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.identifier.doi | 10.1016/j.bbrc.2016.09.150 | - |
dc.contributor.localauthor | Choe, Joonho | - |
dc.contributor.nonIdAuthor | Cha, Seho | - |
dc.contributor.nonIdAuthor | Seo, Taegun | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | KSHV | - |
dc.subject.keywordAuthor | vIRF3 | - |
dc.subject.keywordAuthor | TCF-dependent transcription | - |
dc.subject.keywordAuthor | Wnt signaling pathway | - |
dc.subject.keywordPlus | INTERFERON-REGULATORY FACTOR-3 | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | LATENT | - |
dc.subject.keywordPlus | LANA2 | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | TARGET | - |
dc.subject.keywordPlus | SIGNAL | - |
dc.subject.keywordPlus | ALPHA | - |
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