DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Mikyung | ko |
dc.contributor.author | Kim, Hee Eun | ko |
dc.contributor.author | Park, Eun Byeol | ko |
dc.contributor.author | Lee, Janghyun | ko |
dc.contributor.author | Kim, Kihun | ko |
dc.contributor.author | Lim, Kyungeun | ko |
dc.contributor.author | Yum, Seoyun | ko |
dc.contributor.author | Lee, Younghoon | ko |
dc.contributor.author | Kang, Suk-Jo | ko |
dc.contributor.author | Lee, Joon-Hwa | ko |
dc.contributor.author | Choi, Byong-Seok | ko |
dc.date.accessioned | 2016-12-14T01:46:54Z | - |
dc.date.available | 2016-12-14T01:46:54Z | - |
dc.date.created | 2016-06-22 | - |
dc.date.created | 2016-06-22 | - |
dc.date.created | 2016-06-22 | - |
dc.date.created | 2016-06-22 | - |
dc.date.issued | 2016-09 | - |
dc.identifier.citation | NUCLEIC ACIDS RESEARCH, v.44, no.17, pp.8407 - 8416 | - |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.uri | http://hdl.handle.net/10203/214799 | - |
dc.description.abstract | Retinoic acid-inducible gene I (RIG-I) recognizes specific molecular patterns of viral RNAs for inducing type I interferon. The C-terminal domain (CTD) of RIG-I binds to double-stranded RNA (dsRNA) with the 5'-triphosphate (5'-PPP), which induces a conformational change in RIG-I to an active form. It has been suggested that RIG-I detects infection of influenza A virus by recognizing the 5'-triphosphorylated panhandle structure of the viral RNA genome. Influenza panhandle RNA has a unique structure with a sharp helical bending. In spite of extensive studies of how viral RNAs activate RIG-I, whether the structural elements of the influenza panhandle RNA confer the ability to activate RIG-I signaling has been poorly explored. Here, we investigated the dynamics of the influenza panhandle RNA in complex with RIG-I CTD using NMR spectroscopy and showed that the bending structure of the panhandle RNA negates the requirement of a 5'-PPP moiety for RIG-I activation. | - |
dc.language | English | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | Structural features of influenza A virus panhandle RNA enabling the activation of RIG-I independently of 5'-triphosphate | - |
dc.type | Article | - |
dc.identifier.wosid | 000386158800037 | - |
dc.identifier.scopusid | 2-s2.0-84991247078 | - |
dc.type.rims | ART | - |
dc.citation.volume | 44 | - |
dc.citation.issue | 17 | - |
dc.citation.beginningpage | 8407 | - |
dc.citation.endingpage | 8416 | - |
dc.citation.publicationname | NUCLEIC ACIDS RESEARCH | - |
dc.identifier.doi | 10.1093/nar/gkw525 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Lee, Younghoon | - |
dc.contributor.localauthor | Kang, Suk-Jo | - |
dc.contributor.localauthor | Choi, Byong-Seok | - |
dc.contributor.nonIdAuthor | Lee, Mikyung | - |
dc.contributor.nonIdAuthor | Kim, Hee Eun | - |
dc.contributor.nonIdAuthor | Lee, Janghyun | - |
dc.contributor.nonIdAuthor | Yum, Seoyun | - |
dc.contributor.nonIdAuthor | Lee, Joon-Hwa | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | DOUBLE-STRANDED-RNA | - |
dc.subject.keywordPlus | VIRAL-RNA | - |
dc.subject.keywordPlus | PATTERN-RECOGNITION | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | BASE-PAIR | - |
dc.subject.keywordPlus | SELF-RNA | - |
dc.subject.keywordPlus | TRIPHOSPHATE | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | HELICASE | - |
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