DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Sang Min | ko |
dc.contributor.author | Shin, Sung-Young | ko |
dc.contributor.author | Cho, Kwang-Hyun | ko |
dc.date.accessioned | 2016-11-09T06:27:00Z | - |
dc.date.available | 2016-11-09T06:27:00Z | - |
dc.date.created | 2016-10-27 | - |
dc.date.created | 2016-10-27 | - |
dc.date.issued | 2016-09 | - |
dc.identifier.citation | PLOS ONE, v.11, no.9 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/10203/213867 | - |
dc.description.abstract | Revealing the hidden mechanism of how cells sense and react to environmental signals has been a central question in cell biology. We focused on the rate of increase of stimulation, or temporal gradient, known to cause different responses of cells. We have investigated all possible three-node enzymatic networks and identified a network motif that robustly generates a transient or sustained response by acute or gradual stimulation, respectively. We also found that a regulated double-negative feedback within the motif is essential for the temporal gradient-sensitive switching. Our analysis highlights the essential structure and mechanism enabling cells to properly respond to dynamic environmental changes | - |
dc.language | English | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | A Regulated Double-Negative Feedback Decodes the Temporal Gradient of Input Stimulation in a Cell Signaling Network | - |
dc.type | Article | - |
dc.identifier.wosid | 000382855600113 | - |
dc.identifier.scopusid | 2-s2.0-84990913255 | - |
dc.type.rims | ART | - |
dc.citation.volume | 11 | - |
dc.citation.issue | 9 | - |
dc.citation.publicationname | PLOS ONE | - |
dc.identifier.doi | 10.1371/journal.pone.0162153 | - |
dc.contributor.localauthor | Cho, Kwang-Hyun | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | SYSTEMS BIOLOGY | - |
dc.subject.keywordPlus | DYNAMICS | - |
dc.subject.keywordPlus | FATE | - |
dc.subject.keywordPlus | TRANSDUCTION | - |
dc.subject.keywordPlus | INFORMATION | - |
dc.subject.keywordPlus | BISTABILITY | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordPlus | COORDINATE | - |
dc.subject.keywordPlus | MOTIFS | - |
dc.subject.keywordPlus | KINASE | - |
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