DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mulay, Sandip V. | ko |
dc.contributor.author | Choi, Minsuk | ko |
dc.contributor.author | Jang, Yoon Jeong | ko |
dc.contributor.author | Kim, Youngsam | ko |
dc.contributor.author | Jon, Sangyong | ko |
dc.contributor.author | Churchill, David G | ko |
dc.date.accessioned | 2016-09-08T00:49:13Z | - |
dc.date.available | 2016-09-08T00:49:13Z | - |
dc.date.created | 2016-09-05 | - |
dc.date.created | 2016-09-05 | - |
dc.date.issued | 2016-07 | - |
dc.identifier.citation | CHEMISTRY-A EUROPEAN JOURNAL, v.22, no.28, pp.9642 - 9648 | - |
dc.identifier.issn | 0947-6539 | - |
dc.identifier.uri | http://hdl.handle.net/10203/212913 | - |
dc.description.abstract | Two closely related phenyl selenyl based boron-di-pyrromethene (BODIPY) turn-on fluorescent probes for the detection of hypochlorous acid (HOCl) were synthesized for studies in chemical biology; emission intensity is modulated by a photoinduced electron-transfer (PET) process. Probe 2 intrinsically shows a negligible background signal; however, after reaction with HOCl, chemical oxidation of selenium forecloses the PET process, which evokes a significant increase in fluorescence intensity. The fluorescence intensity of probes 1 and 2 with HOCl involves an similar to 18 and similar to 50-fold enhancement compared with the respective responses from other reactive oxygen/nitrogen species (ROS/RNS) and low detection limits (30.9 nM for 1 and 4.5 nM for 2). Both probes show a very fast response with HOCl; emission intensity reached a maximum within 1 s. These probes show high selectivity for HOCl, as confirmed by confocal microscopy imaging when testing with RAW264.7 and MCF-7 cells | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | HUMAN ATHEROSCLEROTIC LESIONS | - |
dc.subject | INDUCED HOCL PRODUCTION | - |
dc.subject | SELECTIVE DETECTION | - |
dc.subject | RUTHENIUM(II) COMPLEX | - |
dc.subject | NEUTROPHIL PHAGOSOME | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | REACTIVE OXYGEN | - |
dc.subject | BODIPY DYES | - |
dc.subject | LIVE CELLS | - |
dc.subject | PROBE | - |
dc.title | Enhanced Fluorescence Turn-on Imaging of Hypochlorous Acid in Living Immune and Cancer Cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000380271400028 | - |
dc.identifier.scopusid | 2-s2.0-84973141721 | - |
dc.type.rims | ART | - |
dc.citation.volume | 22 | - |
dc.citation.issue | 28 | - |
dc.citation.beginningpage | 9642 | - |
dc.citation.endingpage | 9648 | - |
dc.citation.publicationname | CHEMISTRY-A EUROPEAN JOURNAL | - |
dc.identifier.doi | 10.1002/chem.201601270 | - |
dc.contributor.localauthor | Jon, Sangyong | - |
dc.contributor.localauthor | Churchill, David G | - |
dc.contributor.nonIdAuthor | Mulay, Sandip V. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | biosensing | - |
dc.subject.keywordAuthor | BODIPY | - |
dc.subject.keywordAuthor | fluorescence | - |
dc.subject.keywordAuthor | hypochlorous acid | - |
dc.subject.keywordAuthor | photoinduced electron transfer | - |
dc.subject.keywordPlus | HUMAN ATHEROSCLEROTIC LESIONS | - |
dc.subject.keywordPlus | INDUCED HOCL PRODUCTION | - |
dc.subject.keywordPlus | SELECTIVE DETECTION | - |
dc.subject.keywordPlus | RUTHENIUM(II) COMPLEX | - |
dc.subject.keywordPlus | NEUTROPHIL PHAGOSOME | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | REACTIVE OXYGEN | - |
dc.subject.keywordPlus | BODIPY DYES | - |
dc.subject.keywordPlus | LIVE CELLS | - |
dc.subject.keywordPlus | PROBE | - |
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