Both H4K20 mono-methylation and H3K56 acetylation mark transcription-dependent histone turnover in fission yeast

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Nucleosome dynamics facilitated by histone turnover is required for transcription as well as DNA replication and repair. Histone turnover is often associated with various histone modifications such as H3K56 acetylation (H3K56Ac), H3K36 methylation (H3K36me), and H4K20 methylation (H4K20me). In order to correlate histone modifications and transcription-dependent histone turnover, we performed genome wide analyses for euchromatic regions in G2/M-arrested fission yeast The results show that transcription-dependent histone turnover at 5' promoter and 3' termination regions is directly correlated with the occurrence of H3K56Ac and H4K20 mono-methylation (H4K20me1) in actively transcribed genes. Furthermore, the increase of H3K56Ac and H4K20me1 and antisense RNA production was observed in the absence of the histone H3K36 methyltransferase Sett and histone deacetylase complex (HDAC) that are involved in the suppression of histone turnover within the coding regions. These results together indicate that H4K20me1 as well as H3K56Ac are bona fide marks for transcription-dependent histone turnover in fission yeast. (C) 2016 Elsevier Inc. All rights reserved
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Issue Date
2016-08
Language
English
Article Type
Article
Keywords

RNA-POLYMERASE-II; CHROMATIN-STRUCTURE; NUCLEOSOME; REPLICATION; EXCHANGE; GENES; H3; SUPPRESSION; ELONGATION; STABILITY

Citation

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.476, no.4, pp.515 - 521

ISSN
0006-291X
DOI
10.1016/j.bbrc.2016.05.155
URI
http://hdl.handle.net/10203/212548
Appears in Collection
BS-Journal Papers(저널논문)
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