Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems

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Carbon dioxide ( CO2) elicits different olfactory behaviors across species. In Drosophila, neurons that detect CO2 are located in the antenna, form connections in a ventral glomerulus in the antennal lobe, and mediate avoidance. By contrast, in the mosquito these neurons are in the maxillary palps ( MPs), connect to medial sites, and promote attraction. We found in Drosophila that loss of a microRNA, miR- 279, leads to formation of CO2 neurons in the MPs. miR- 279 acts through down- regulation of the transcription factor Nerfin- 1. The ectopic neurons are hybrid cells. They express CO2 receptors and form connections characteristic of CO2 neurons, while exhibiting wiring and receptor characteristics of MP olfactory receptor neurons ( ORNs). We propose that this hybrid ORN reveals a cellular intermediate in the evolution of species- specific behaviors elicited by CO2
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Issue Date
2008-02
Language
English
Article Type
Article
Keywords

CENTRAL PROJECTIONS; RECEPTOR NEURONS; AEDES-AEGYPTI; DROSOPHILA; MAXILLARY; SENSILLA; MOTHS

Citation

SCIENCE, v.319, no.5867, pp.1256 - 1260

ISSN
0036-8075
DOI
10.1126/science.1149483
URI
http://hdl.handle.net/10203/211915
Appears in Collection
BS-Journal Papers(저널논문)
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