Taste-independent detection of the caloric content of sugar in Drosophila

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Feeding behavior is influenced primarily by two factors: nutritional needs and food palatability. However, the role of food deprivation and metabolic needs in the selection of appropriate food is poorly understood. Here, we show that the fruit fly, Drosophila melanogaster, selects calorie-rich foods following prolonged food deprivation in the absence of taste-receptor signaling. Flies mutant for the sugar receptors Gr5a and Gr64a cannot detect the taste of sugar, but still consumed sugar over plain agar after 15 h of starvation. Similarly, pox-neuro mutants that are insensitive to the taste of sugar preferentially consumed sugar over plain agar upon starvation. Moreover, when given a choice between metabolizable sugar (sucrose or D-glucose) and nonmetabolizable (zero-calorie) sugar (sucralose or L-glucose), starved Gr5a; Gr64a double mutants preferred metabolizable sugars. These findings suggest the existence of a taste-independent metabolic sensor that functions in food selection. The preference for calorie-rich food correlates with a decrease in the two main hemolymph sugars, trehalose and glucose, and in glycogen stores, indicating that this sensor is triggered when the internal energy sources are depleted. Thus, the need to replenish depleted energy stores during periods of starvation may be met through the activity of a taste-independent metabolic sensing pathway
Publisher
NATL ACAD SCIENCES
Issue Date
2011-07
Language
English
Article Type
Article
Keywords

SENSING NEURONS; POX-NEURO; RECEPTOR; GLUCOSE; GENE; TREHALOSE; BEHAVIOR; MELANOGASTER; SENSOR; GLUCOKINASE

Citation

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.108, no.28, pp.11644 - 11649

ISSN
0027-8424
DOI
10.1073/pnas.1017096108
URI
http://hdl.handle.net/10203/211910
Appears in Collection
BS-Journal Papers(저널논문)
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