Taste-independent nutrient selection is mediated by a brain-specific Na+/solute co-transporter in Drosophila

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Animals can determine the nutritional value of sugar without the influence of taste. We examined a Drosophila mutant that is insensitive to the nutritional value of sugars, responding only to the concentration (that is, sweetness). The affected gene encodes a sodium/solute co-transporter-like protein, designated SLC5A11 (or cupcake), which is structurally similar to mammalian sodium/glucose co-transporters that transport sugar across the intestinal and renal lumen. However, SLC5A11 was prominently expressed in 10-13 pairs of R4 neurons of the ellipsoid body in the brain and functioned in these neurons for selecting appropriate foods
Publisher
NATURE PUBLISHING GROUP
Issue Date
2013-05
Language
English
Article Type
Article
Keywords

STEM-CELLS; GLUCOSE; BEHAVIOR; MIDGUT; MEMORY; SUGAR

Citation

NATURE NEUROSCIENCE, v.16, no.5, pp.526 - +

ISSN
1097-6256
DOI
10.1038/nn.3372
URI
http://hdl.handle.net/10203/211906
Appears in Collection
BS-Journal Papers(저널논문)
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