Natural killer cells regulate eosinophilic inflammation in chronic rhinosinusitis

Cited 10 time in webofscience Cited 0 time in scopus
  • Hit : 385
  • Download : 275
Eosinophils play a major pathologic role in the pathogenesis of diverse inflammatory diseases including chronic rhinosinusitis (CRS). Dysregulated production of prostaglandin (PG), particularly PGD(2), is considered to be an important contributing factor to eosinophilic inflammation in CRS primarily through proinflammatory and chemotactic effects on eosinophils. Here, we provide evidence that PGD(2) can promote eosinophilic inflammation through a suppression of Natural killer (NK) cell effector function and NK cell-mediated eosinophil regulation. Eosinophil apoptosis mediated by NK cells was significantly decreased in CRS patients compared with healthy controls. This decrease was associated with NK cell dysfunction and eosinophilic inflammation. Tissue eosinophils were positively correlated with blood eosinophils in CRS patients. In a murine model of CRS, NK cell depletion caused an exacerbation of blood eosinophilia and eosinophilic inflammation in the sinonasal tissue. PGD(2) and its metabolite, but not PGE(2) and a panel of cytokines including TGF-beta, were increased in CRS patients compared with controls. Effector functions of NK cells were potently suppressed by PGD(2)-dependent, rather than PGE(2)-dependent, pathway in controls and CRS patients. Thus, our results suggest decreased NK cell-mediated eosinophil regulation, possibly through an increased level of PGD(2), as a previously unrecognized link between PG dysregulation and eosinophilic inflammation in CRS
Publisher
NATURE PUBLISHING GROUP
Issue Date
2016-06
Language
English
Article Type
Article
Keywords

NASAL POLYPS; NK CELLS; TISSUE EOSINOPHILIA; PROSTAGLANDIN D-2; APOPTOSIS; ASTHMA; RECEPTOR; INHIBITION; MECHANISM; CYTOTOXICITY

Citation

SCIENTIFIC REPORTS, v.6

ISSN
2045-2322
DOI
10.1038/srep27615
URI
http://hdl.handle.net/10203/210178
Appears in Collection
MSE-Journal Papers(저널논문)
Files in This Item
95852.pdf(2.16 MB)Download
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 10 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0