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College of Life Science and Bioengineering(생명과학기술대학)Dept. of Biological Sciences(생명과학과)BS-Journal Papers(저널논문)

Synthesis of Bispecific Antibodies using Genetically Encoded Unnatural Amino Acids

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dc.contributor.authorKim, Chan Hyukko
dc.contributor.authorAxup, Jun Y.ko
dc.contributor.authorDubrovska, Annako
dc.contributor.authorKazane, Stephanie A.ko
dc.contributor.authorHutchins, Benjamin A.ko
dc.contributor.authorWold, Erik D.ko
dc.contributor.authorSmider, Vaughn V.ko
dc.contributor.authorSchultz, Peter G.ko
dc.date.accessioned2016-07-04T06:03:21Z-
dc.date.available2016-07-04T06:03:21Z-
dc.date.created2016-05-13-
dc.date.created2016-05-13-
dc.date.created2016-05-13-
dc.date.issued2012-06-
dc.identifier.citationJOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.134, no.24, pp.9918 - 9921-
dc.identifier.issn0002-7863-
dc.identifier.urihttp://hdl.handle.net/10203/209140-
dc.description.abstractBispecific antibodies were constructed using genetically encoded unnatural amino acids with orthogonal chemical reactivity. A two-step process afforded homogeneous products in excellent yield. Using this approach, we synthesized an anti-HER2/anti-CD3 bispecific antibody, which efficiently cross-linked HER2+ cells and CD3+ cells. In vitro effector-cell mediated cytotoxicity was observed at picomolar concentrations.-
dc.languageEnglish-
dc.publisherAMER CHEMICAL SOC-
dc.subjectCANCER-THERAPY-
dc.subjectTUMOR-CELLS-
dc.subjectT-CELLS-
dc.subjectFRAGMENTS-
dc.subjectIDENTIFICATION-
dc.subjectRESIDUES-
dc.subjectCODE-
dc.subjectFAB-
dc.titleSynthesis of Bispecific Antibodies using Genetically Encoded Unnatural Amino Acids-
dc.typeArticle-
dc.identifier.wosid000305358900024-
dc.identifier.scopusid2-s2.0-84862538751-
dc.type.rimsART-
dc.citation.volume134-
dc.citation.issue24-
dc.citation.beginningpage9918-
dc.citation.endingpage9921-
dc.citation.publicationnameJOURNAL OF THE AMERICAN CHEMICAL SOCIETY-
dc.identifier.doi10.1021/ja303904e-
dc.contributor.localauthorKim, Chan Hyuk-
dc.contributor.nonIdAuthorAxup, Jun Y.-
dc.contributor.nonIdAuthorDubrovska, Anna-
dc.contributor.nonIdAuthorKazane, Stephanie A.-
dc.contributor.nonIdAuthorHutchins, Benjamin A.-
dc.contributor.nonIdAuthorWold, Erik D.-
dc.contributor.nonIdAuthorSmider, Vaughn V.-
dc.contributor.nonIdAuthorSchultz, Peter G.-
dc.type.journalArticleArticle-
dc.subject.keywordPlusCANCER-THERAPY-
dc.subject.keywordPlusTUMOR-CELLS-
dc.subject.keywordPlusT-CELLS-
dc.subject.keywordPlusFRAGMENTS-
dc.subject.keywordPlusIDENTIFICATION-
dc.subject.keywordPlusRESIDUES-
dc.subject.keywordPlusCODE-
dc.subject.keywordPlusFAB-
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