DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hayashi, Makoto | ko |
dc.contributor.author | Majumdar, Arindam | ko |
dc.contributor.author | Li, Xiujuan | ko |
dc.contributor.author | Adler, Jeremy | ko |
dc.contributor.author | Sun, Zuyue | ko |
dc.contributor.author | Vertuani, Simona | ko |
dc.contributor.author | Hellberg, Carina | ko |
dc.contributor.author | Mellberg, Sofie | ko |
dc.contributor.author | Koch, Sina | ko |
dc.contributor.author | Dimberg, Anna | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.contributor.author | Dejana, Elisabetta | ko |
dc.contributor.author | Belting, Heinz-Georg | ko |
dc.contributor.author | Affolter, Markus | ko |
dc.contributor.author | Thurston, Gavin | ko |
dc.contributor.author | Holmgren, Lars | ko |
dc.contributor.author | Vestweber, Dietmar | ko |
dc.contributor.author | Claesson-Welsh, Lena | ko |
dc.date.accessioned | 2016-07-04T02:44:07Z | - |
dc.date.available | 2016-07-04T02:44:07Z | - |
dc.date.created | 2013-05-28 | - |
dc.date.created | 2013-05-28 | - |
dc.date.issued | 2013-04 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v.4 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10203/208979 | - |
dc.description.abstract | Vascular endothelial growth factor (VEGF) guides the path of new vessel sprouts by inducing VEGF receptor-2 activity in the sprout tip. In the stalk cells of the sprout, VEGF receptor-2 activity is downregulated. Here, we show that VEGF receptor-2 in stalk cells is dephosphorylated by the endothelium-specific vascular endothelial-phosphotyrosine phosphatase (VE-PTP). VE-PTP acts on VEGF receptor-2 located in endothelial junctions indirectly, via the Angiopoietin-1 receptor Tie2. VE-PTP inactivation in mouse embryoid bodies leads to excess VEGF receptor-2 activity in stalk cells, increased tyrosine phosphorylation of VE-cadherin and loss of cell polarity and lumen formation. Vessels in ve-ptp(-/-) teratomas also show increased VEGF receptor-2 activity and loss of endothelial polarization. Moreover, the zebrafish VE-PTP orthologue ptp-rb is essential for polarization and lumen formation in intersomitic vessels. We conclude that the role of Tie2 in maintenance of vascular quiescence involves VE-PTP-dependent dephosphorylation of VEGF receptor-2, and that VEGF receptor-2 activity regulates VE-cadherin tyrosine phosphorylation, endothelial cell polarity and lumen formation. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | BLOOD-VESSEL DEVELOPMENT | - |
dc.subject | RECEPTOR-TYROSINE KINASE | - |
dc.subject | GROWTH-FACTOR RECEPTOR-2 | - |
dc.subject | SIGNAL-TRANSDUCTION | - |
dc.subject | TUMOR ANGIOGENESIS | - |
dc.subject | ZEBRAFISH EMBRYO | - |
dc.subject | TIE2 RECEPTOR | - |
dc.subject | ANGIOPOIETIN-1 | - |
dc.subject | CADHERIN | - |
dc.subject | PHOSPHATASE | - |
dc.title | VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation | - |
dc.type | Article | - |
dc.identifier.wosid | 000318872100029 | - |
dc.identifier.scopusid | 2-s2.0-84877788239 | - |
dc.type.rims | ART | - |
dc.citation.volume | 4 | - |
dc.citation.publicationname | NATURE COMMUNICATIONS | - |
dc.identifier.doi | 10.1038/ncomms2683 | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | Hayashi, Makoto | - |
dc.contributor.nonIdAuthor | Majumdar, Arindam | - |
dc.contributor.nonIdAuthor | Li, Xiujuan | - |
dc.contributor.nonIdAuthor | Adler, Jeremy | - |
dc.contributor.nonIdAuthor | Sun, Zuyue | - |
dc.contributor.nonIdAuthor | Vertuani, Simona | - |
dc.contributor.nonIdAuthor | Hellberg, Carina | - |
dc.contributor.nonIdAuthor | Mellberg, Sofie | - |
dc.contributor.nonIdAuthor | Koch, Sina | - |
dc.contributor.nonIdAuthor | Dimberg, Anna | - |
dc.contributor.nonIdAuthor | Dejana, Elisabetta | - |
dc.contributor.nonIdAuthor | Belting, Heinz-Georg | - |
dc.contributor.nonIdAuthor | Affolter, Markus | - |
dc.contributor.nonIdAuthor | Thurston, Gavin | - |
dc.contributor.nonIdAuthor | Holmgren, Lars | - |
dc.contributor.nonIdAuthor | Vestweber, Dietmar | - |
dc.contributor.nonIdAuthor | Claesson-Welsh, Lena | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | BLOOD-VESSEL DEVELOPMENT | - |
dc.subject.keywordPlus | RECEPTOR-TYROSINE KINASE | - |
dc.subject.keywordPlus | GROWTH-FACTOR RECEPTOR-2 | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | TUMOR ANGIOGENESIS | - |
dc.subject.keywordPlus | ZEBRAFISH EMBRYO | - |
dc.subject.keywordPlus | TIE2 RECEPTOR | - |
dc.subject.keywordPlus | ANGIOPOIETIN-1 | - |
dc.subject.keywordPlus | CADHERIN | - |
dc.subject.keywordPlus | PHOSPHATASE | - |
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